Absorption and presentation of antigens by epithelial cells of the small intestine: Hyptheses and predictions relating to the pathogenesis of coeliac disease

dc.contributor.author	Mayrhofer, G.
dc.date.issued	1995
dc.description.abstract	<jats:title>Summary</jats:title><jats:p>Effects of the route of antigen absorption and presentation in the small intestine are discussed in relation to outcomes from antigen exposure. It is proposed that antigens presented by epithelial cells to intrinsic T cell populations in the mucosa induce anti‐inflammatory immune responses, while antigens presented to conventional T cells by lamina propria APC predisposes to inflammation. The pathogenesis of coeliac disease is attributed to three factors: a defect in antigen processing by epithelial cells; the intrinsic properties of the gliadins; and the HLA‐D haplotype of the individual. It is suggested that MHC class II molecules play a role in antigen uptake by enterocytes, in addition to their function in antigen presentation to T cells.</jats:p>
dc.identifier.citation	Immunology and Cell Biology, 1995; 73(5):433-439
dc.identifier.doi	10.1038/icb.1995.67
dc.identifier.issn	0818-9641
dc.identifier.issn	1440-1711
dc.identifier.uri	http://hdl.handle.net/2440/11579
dc.language.iso	en
dc.publisher	University of Adelaide
dc.source.uri	https://doi.org/10.1038/icb.1995.67
dc.title	Absorption and presentation of antigens by epithelial cells of the small intestine: Hyptheses and predictions relating to the pathogenesis of coeliac disease
dc.type	Journal article
pubs.publication-status	Published

Collections