Biomechancial Quantification of Pathologic Manipulable Spinal Lesions: An In Vivo Ovine Model of Spondylolysis and Intervertebral Disc Degeneration

Simple item page
dc.contributor.authorColloca, C.
dc.contributor.authorGunzburg, R.
dc.contributor.authorFreeman, B.
dc.contributor.authorSzpalski, M.
dc.contributor.authorAfifi, M.
dc.contributor.authorMoore, R.
dc.date.issued2012
dc.description.abstractObjective: The purposes of this study were to quantify the biomechanical and pathologic consequences of surgically induced spinal lesions and to determine their response to spinal manipulation (SMT) in an in vivo ovine model. Methods: Of 24 Merino sheep, 6 received L5 spondylolytic defects, 6 received L1 annular lesions, and 12 served as respective controls. Dorsoventral (DV) stiffness was assessed using oscillatory loads (2-12 Hz). Two SMT force-time profiles were administered in each of the groups using a randomized and repeated-measures design. Stiffness and the effect of SMT on the DV motions and multifidus needle electromyographic responses were assessed using a repeated-measures analysis of variance (α = .05). Postmortem histologic analysis and computed tomography validated the presence of lesions. Results: L5 DV stiffness was significantly increased (40.2%) in the spondylolysis (6.28 N/mm) compared with the L5 control group (4.48 N/mm) (P < 03). Spinal manipulations delivered to the spondylolysis group resulted in less DV vertebral displacement (P < .01) compared with controls. Dorsoventral stiffness of the disc degeneration group was 5.66 N/mm, 94.5% greater than in the L1 control group (2.91 N/mm) (P < .01). One hundred–millisecond SMTs resulted in significantly reduced DV displacements in the disc degeneration group compared with the L1 control group (P < .01). Animals in the disc degeneration group showed a consistent 25% to 30% reduction in needle electromyographic responses to all SMTs. Conclusions: Quantifiable objective evidence of spinal lesions and their response to SMT were confirmed in this study. Neuromechanical alterations provide novel insights into quantifying manipulable spinal lesions and a means to biomechanically assess SMT outcomes.
dc.description.statementofresponsibilityChristopher J. Colloca, Robert Gunzburg, Brian J. Freeman, Marek Szpalski, Mostafa Afifi, and Robert J. Moore
dc.identifier.citationJournal of Manipulative and Physiological Therapeutics, 2012; 35(5):354-366
dc.identifier.doi10.1016/j.jmpt.2012.04.018
dc.identifier.issn0161-4754
dc.identifier.issn1532-6586
dc.identifier.orcidFreeman, B. [0000-0003-0237-9707]
dc.identifier.urihttp://hdl.handle.net/2440/73047
dc.language.isoen
dc.publisherMosby Inc
dc.rightsCopyright © 2012 National University of Health Sciences.
dc.source.urihttps://doi.org/10.1016/j.jmpt.2012.04.018
dc.subjectBiomechanics
dc.subjectManipulation, Spinal
dc.subjectSpondylolysis
dc.subjectIntervertebral Disc Degeneration
dc.subjectChiropractic
dc.titleBiomechancial Quantification of Pathologic Manipulable Spinal Lesions: An In Vivo Ovine Model of Spondylolysis and Intervertebral Disc Degeneration
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Orthopaedics and Trauma publications