Direct measurement of compression spring constant of single DNA molecule with AFM.

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dc.contributor.authorZhou, X.
dc.contributor.authorAn, H.
dc.contributor.authorGuo, Y.
dc.contributor.authorSun, J.
dc.contributor.authorLi, M.
dc.contributor.authorHu, J.
dc.date.issued2005
dc.description.abstractIn this paper, a new approach is demonstrated to measure the compression elasticity of single biomolecule in small force regime (<0.5 nN) using vibrating mode scanning polarization force microscopy (VSPFM). With this method we investigate the compression elasticity of a single DNA molecule in the radial direction (perpendicular to DNA strands). The radial deformation of DNA molecules deposited on mica surface is shown to be able to reach about 50% under external load, and this remarkable deformation is reversible. In addition, the compression spring constant of DNA molecules is estimated to be about 0.6 nN/nm according to the height-force curves.
dc.description.statementofresponsibilityZhou Xingfei, An Hongjie, Guo Yunchang, Sun Jielin, Li Minqian and Hu Jun
dc.identifier.citationChinese Science Bulletin, 2005; 50(10):954-957
dc.identifier.doi10.1360/982005-161
dc.identifier.issn1001-6538
dc.identifier.urihttp://hdl.handle.net/2440/55819
dc.language.isoen
dc.publisherScience Press
dc.source.urihttps://doi.org/10.1360/982005-161
dc.subjectatomic force microscopy
dc.subjectsingle DNA molecule
dc.subjectelasticity
dc.titleDirect measurement of compression spring constant of single DNA molecule with AFM.
dc.typeJournal article
pubs.publication-statusPublished

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