The pharmacology of gastrointestinal nociceptive pathways
Date
2002
Authors
Blackshaw, L.
Gebhart, G.
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Type:
Journal article
Citation
Current Opinion in Pharmacology, 2002; 2(6):642-649
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Abstract
The principal conscious sensations that arise from the gastrointestinal tract are discomfort and pain. Chronic visceral discomfort and pain are generally managed poorly with currently available pharmacological agents. Receptors and ion channels present on extrinsic visceral primary afferent (sensory) neurons are targets for the development of new pharmacological strategies for control of visceral pain.