Genetic and clinical contributions to cerebral palsy: A multi-variable analysis

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dc.contributor.authorO'Callaghan, M.
dc.contributor.authorMacLennan, A.
dc.contributor.authorGibson, C.
dc.contributor.authorMcMichael, G.
dc.contributor.authorHaan, E.
dc.contributor.authorBroadbent, J.
dc.contributor.authorBaghurst, P.
dc.contributor.authorGoldwater, P.
dc.contributor.authorDekker, G.
dc.date.issued2013
dc.descriptionAll authors are contributors to the Australian Collaborative Cerebral Palsy Research Group The definitive version is available at www.wileyonlinelibrary.com
dc.description.abstract<h4>Aim</h4>This study aims to examine single nucleotide polymorphism (SNP) associations with cerebral palsy in a multi-variable analysis adjusting for potential clinical confounders and to assess SNP-SNP and SNP-maternal infection interactions as contributors to cerebral palsy.<h4>Methods</h4>A case control study including 587 children with cerebral palsy and 1154 control children without cerebral palsy. Thirty-nine candidate SNPs were genotyped in both mother and child. Data linkage to perinatal notes and cerebral palsy registers was performed with a supplementary maternal pregnancy questionnaire. History of known maternal infection during pregnancy was extracted from perinatal databases.<h4>Results</h4>Both maternal and fetal carriage of inducible nitric oxide synthase SNP rs1137933 were significantly negatively associated with cerebral palsy in infants born at less than 32 weeks gestation after adjustment for potential clinical confounders and correction for multiple testing (odds ratio 0.55, 95% confidence interval 0.38-0.79; odds ratio 0.57, 95% confidence interval 0.4-0.82, respectively). Analysis did not show any statistically significant SNP-SNP or SNP-maternal infection interactions after correction for multiple testing.<h4>Conclusions</h4>Maternal and child inducible nitric oxide synthase SNPs are associated with reduced risk of cerebral palsy in infants born very preterm. There was no evidence for statistically significant SNP-SNP or SNP-maternal infection interactions as modulators of cerebral palsy risk.
dc.description.statementofresponsibilityMichael E O’Callaghan, Alastair H MacLennan, Catherine S Gibson, Gai L McMichael, Eric A Haan, Jessica L Broadbent, Peter A Baghurst, Paul N Goldwater, Gustaaf A Dekker and for the Australian Collaborative Cerebral Palsy Research Group
dc.identifier.citationJournal of Paediatrics and Child Health, 2013; 49(7):575-581
dc.identifier.doi10.1111/jpc.12279
dc.identifier.issn1034-4810
dc.identifier.issn1440-1754
dc.identifier.orcidO'Callaghan, M. [0000-0001-5038-5859] [0000-0002-8178-9714]
dc.identifier.orcidMcMichael, G. [0000-0002-6811-5301]
dc.identifier.orcidHaan, E. [0000-0002-7310-5124]
dc.identifier.orcidGoldwater, P. [0000-0003-4822-8488]
dc.identifier.orcidDekker, G. [0000-0002-7362-6683]
dc.identifier.urihttp://hdl.handle.net/2440/80004
dc.language.isoen
dc.publisherBlackwell Publishing Asia
dc.relation.grantNHMRC
dc.rights© 2013 The Authors.
dc.source.urihttps://doi.org/10.1111/jpc.12279
dc.subjectcase control
dc.subjectcerebral palsy
dc.subjectinfection
dc.subjectinteraction
dc.subjectpregnancy
dc.subjectSNP
dc.titleGenetic and clinical contributions to cerebral palsy: A multi-variable analysis
dc.typeJournal article
pubs.publication-statusPublished

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