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Ibudilast reduces oxaliplatin-induced tactile allodynia and cognitive impairments in rats

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dc.contributor.authorJohnston, I.
dc.contributor.authorTan, M.
dc.contributor.authorCao, J.
dc.contributor.authorMatsos, A.
dc.contributor.authorForrest, D.
dc.contributor.authorSi, E.
dc.contributor.authorFardell, J.
dc.contributor.authorHutchinson, M.
dc.date.issued2017
dc.description.abstractChemotherapy can cause serious neurotoxic side effects, such as painful peripheral neuropathies and disabling cognitive impairments. Four experiments examined whether Ibudilast, a clinically approved neuroimmune therapy, would reduce tactile allodynia and memory impairments caused by oxaliplatin in laboratory rats. Rats received an intraperitoneal injection of oxaliplatin (6mg/kg i.p.) or vehicle and were assessed for tactile allodynia 3 or 5days after injection, memory impairments in the novel object and novel location recognition tests 10-12days after injection, and fear conditioning 14days after injection. Ibudilast (7.5mg/kg) or vehicle was administered prior to oxaliplatin (Experiments 1 and 3) or prior to behavioural testing (Experiments 2 and 4). Ibudilast treatment prior to oxaliplatin prevented the development of tactile allodynia and memory impairments. Ibudilast treatment prior to behavioural testing reduced oxaliplatin-induced tactile allodynia, memory impairments, and impaired renewal of fear conditioning. These results suggest that Ibudilast could be an effective treatment against oxaliplatin-induced neuropathies and cognitive impairments.
dc.description.statementofresponsibilityIan N. Johnstona, Manuela Tana, Jacob Caoa, Antigone Matsosa, Daniel R.L. Forresta, Emily Sia, Joanna E. Fardella, Mark R. Hutchinsonc
dc.identifier.citationBehavioural Brain Research, 2017; 334:109-118
dc.identifier.doi10.1016/j.bbr.2017.07.021
dc.identifier.issn0166-4328
dc.identifier.issn1872-7549
dc.identifier.orcidHutchinson, M. [0000-0003-2154-5950]
dc.identifier.urihttp://hdl.handle.net/2440/110917
dc.language.isoen
dc.publisherElsevier
dc.relation.granthttp://purl.org/au-research/grants/arc/DP110100297
dc.rights© 2017 Elsevier B.V. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.bbr.2017.07.021
dc.subjectOxaliplatin; chemotherapy; neuropathic pain; memory impairment; ibudilast
dc.titleIbudilast reduces oxaliplatin-induced tactile allodynia and cognitive impairments in rats
dc.typeJournal article
pubs.publication-statusPublished

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