Midlife managerial experience is linked to late life hippocampal morphology and function
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Date
2017
Authors
Suo, C.
Gates, N.
Fiatarone Singh, M.
Saigal, N.
Wilson, G.
Meiklejohn, J.
Sachdev, P.
Brodaty, H.
Wen, W.
Singh, N.
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Brain Imaging and Behavior, 2017; 11(2):333-345
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C. Suo, N. Gates, M. Fiatarone Singh, N. Saigal, G. C. Wilson, J. Meiklejohn, P. Sachdev, H. Brodaty, W. Wen, N. Singh, B. T. Baune, M. Baker, N. Foroughi, Y. Wang, Michael J. Valenzuela
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Abstract
An active cognitive lifestyle has been suggested to have a protective role in the long-term maintenance of cognition. Amongst healthy older adults, more managerial or supervisory experiences in midlife are linked to a slower hippocampal atrophy rate in late life. Yet whether similar links exist in individuals with Mild Cognitive Impairment (MCI) is not known, nor whether these differences have any functional implications. 68 volunteers from the Sydney SMART Trial, diagnosed with non-amnestic MCI, were divided into high and low managerial experience (HME/LME) during their working life. All participants underwent neuropsychological testing, structural and resting-state functional MRI. Group comparisons were performed on hippocampal volume, morphology, hippocampal seed-based functional connectivity, memory and executive function and self-ratings of memory proficiency. HME was linked to better memory function (p = 0.024), mediated by larger hippocampal volume (p = 0.025). More specifically, deformation analysis found HME had relatively more volume in the CA1 sub-region of the hippocampus (p < 0.05). Paradoxically, this group rated their memory proficiency worse (p = 0.004), a result correlated with diminished functional connectivity between the right hippocampus and right prefrontal cortex (p < 0.001). Finally, hierarchical regression modelling substantiated this double dissociation.
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© The Author(s) 2016. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.