Emerging therapeutic applications for fumarates
Date
2021
Authors
Hoogendoorn, A.
Avery, T.D.
Li, J.
Bursill, C.
Abell, A.
Grace, P.M.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Trends in Pharmacological Sciences, 2021; 42(4):239-254
Statement of Responsibility
Ayla Hoogendoorn, Thomas D.Avery, Jiahe Li, Christina Bursill, Andrew Abell, Peter M.Grace
Conference Name
Abstract
Fumarates are successfully used for the treatment of psoriasis and multiple sclerosis. Their antioxidative, immunomodulatory, and neuroprotective properties make fumarates attractive therapeutic candidates for other pathologies. The exact working mechanisms of fumarates are, however, not fully understood. Further elucidation of the mechanisms is required if these drugs are to be successfully repurposed for other diseases. Towards this, administration route, dosage, and treatment timing, frequency, and duration are important parameters to consider and optimize with clinical paradigms in mind. Here, we summarize the rapidly expanding literature on the pharmacokinetics and pharmacodynamics of fumarates, including a discussion on two recently FDA-approved fumarates Vumerity<sup>TM</sup> and Bafiertam<sup>TM</sup>. We review emerging applications of fumarates, focusing on neurological and cardiovascular diseases.
School/Discipline
Dissertation Note
Provenance
Description
Access Status
Rights
© 2021 Elsevier Ltd. All rights reserved.