Carbon nanotubes as an advanced drug and gene delivery nanosystem

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dc.contributor.authorDolatabadi, J.
dc.contributor.authorOmidi, Y.
dc.contributor.authorLosic, D.
dc.date.issued2011
dc.description.abstractNew nanomaterials have been extensively explored in recent years for drug delivery applications to address problems associated with the conventional drug therapies such as limited drug solubility, poor biodistribution, lack of selectivity and unfavourable pharmacokinetics. Among them, carbon nanotubes (CNTs) have attracted great attention due to their unique physicochemical architecture and properties. This comprehensive review summarizes the recent advances regarding the use of CNTs for drug delivery. This review includes general information about CNT structures and properties, methods for their dispersion in aqueous solution and basic concepts for CNTs functionalization relevant for their applications in biological systems and delivery of therapeutics. Some toxicological and biocompatibility issues related to the use of CNTs as pharmaceutical excipients are discussed. Last, recent progress on development of CNT drug delivery systems with a specific emphasis on gene delivery was reviewed.
dc.description.statementofresponsibilityJafar Ezzati Nazhad Dolatabadi, Yadollah Omidi and Dusan Losic
dc.identifier.citationCurrent Nanoscience, 2011; 7(3):297-314
dc.identifier.doi10.2174/157341311795542444
dc.identifier.issn1573-4137
dc.identifier.issn1875-6786
dc.identifier.orcidLosic, D. [0000-0002-1930-072X]
dc.identifier.urihttp://hdl.handle.net/2440/84511
dc.language.isoen
dc.publisherBentham Science Publishers
dc.relation.grantARC
dc.rightsCopyright status unknown
dc.source.urihttps://doi.org/10.2174/157341311795542444
dc.titleCarbon nanotubes as an advanced drug and gene delivery nanosystem
dc.typeJournal article
pubs.publication-statusPublished

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