Effect of changes in antibiotic prescribing on patient outcomes in a community setting: A natural experiment in Australia

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dc.contributor.authorBeilby, J.
dc.contributor.authorMarley, J.
dc.contributor.authorWalker, D.
dc.contributor.authorChamberlain, N.
dc.contributor.authorBurke, M.
dc.date.issued2002
dc.description© 2002 by the Infectious Diseases Society of America.
dc.description.abstractThis study examined whether a significant change in antibiotic use caused by an Australian government directive targeted at amoxicillin with clavulanic acid (AC) was associated with changes in prescription share, health care costs, and patient outcomes. We used an integrated database of computerized general practice medical records, which included data regarding 34,242 patients and 318,234 recorded patient visits. There were 15,303 antibiotic prescriptions provided to 9921 patients during a 4-year period, with AC prescribed for 1453 (14.6%) of these patients. A total of 5125 patient outcomes were identified. There was a shift away from best-practice antibiotic prescribing, and a significant association was identified between the rate and cost of process-of-care and patient outcomes and the decrease in AC-prescription share. This policy initiative created unintended changes in prescribing behavior, increased costs to the government, and a trend toward poorer patient outcomes. Detailed analyses are required before instigating initiatives aimed at changing clinicians' prescribing behavior.
dc.description.statementofresponsibilityJustin Beilby, John Marley, Don Walker, Nicole Chamberlain, and Michelle Burke for the FIESTA Study Group
dc.identifier.citationClinical Infectious Diseases, 2002; 34(1):55-64
dc.identifier.doi10.1086/338232
dc.identifier.issn1058-4838
dc.identifier.issn1537-6591
dc.identifier.urihttp://hdl.handle.net/2440/6160
dc.language.isoen
dc.publisherUniv Chicago Press
dc.source.urihttps://doi.org/10.1086/338232
dc.subjectFIESTA Study Group
dc.subjectHumans
dc.subjectAnti-Bacterial Agents
dc.subjectTreatment Outcome
dc.subjectAge Distribution
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectInfant
dc.subjectInfant, Newborn
dc.subjectCommunity Health Services
dc.subjectHealth Care Costs
dc.subjectDrug Utilization
dc.subjectAustralia
dc.subjectFemale
dc.subjectMale
dc.subjectDatabases as Topic
dc.subjectDrug Prescriptions
dc.subjectPractice Patterns, Physicians'
dc.titleEffect of changes in antibiotic prescribing on patient outcomes in a community setting: A natural experiment in Australia
dc.typeJournal article
pubs.publication-statusPublished

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