Developmental origins of cardiac disease: understanding cardiac maturation in pigs
Date
2023
Authors
Dimasi, C.G.
Darby, J.R.T.
Holman, S.
Quinn, M.
Bradshaw, E.L.
Jesse, S.M.
Morrison, J.L.
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Conference item
Citation
Reproductive Sciences, 2023, vol.30, pp.219A-220A
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70th Annual Meeting of the Society for Reproductive Investigation (SRI) (21 Mar 2023 - 25 Mar 2023 : Brisbane, Australia)
Abstract
Ischaemic heart disease (IHD) remains the leading cause of morbidity and mortality worldwide. Treatment of IHD is limited as the adult heart is unable to repair after damage; instead forming nonfunctional scar tissue. This is the result of cardiomyocyte (CM) quiescence,or the inability to proliferate to enable repair. CMs in large mammalian species including humans, sheep and pigs stop proliferating, transition to hypertrophic growth and switch their metabolism from glycolysis to oxidative phosphorylation (OXPHOS) late in gestation. Studies investigating this CM transition period in large animal models are lacking and are necessary to better reflect human physiology. Therefore, we aimed to characterise this critical CM transition period from late gestation and in the early postnatal period in pigs. We hypothesised this transition period would begin to occur in late gestation, being largely complete by birth.This will allow us to better understand if using pigs is a suitable model for developing interventions/therapeutics against IHD in humans
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Copyright 2023 Springer