The association between inherited cytokine polymorphisms and cerebral palsy

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dc.contributor.authorGibson, C.
dc.contributor.authorMacLennan, A.
dc.contributor.authorGoldwater, P.
dc.contributor.authorHaan, E.
dc.contributor.authorPriest, K.
dc.contributor.authorDekker, G.
dc.contributor.authorHague, W.
dc.contributor.authorMorton, M.
dc.date.issued2006
dc.description.abstractObjective The purpose of this study was to investigate associations between inherited cytokine polymorphisms and cerebral palsy. Study design This was a case-control study that used DNA from the newborn infant screening cards of 443 white infants with cerebral palsy and 883 white control infants to test for the following cytokine polymorphisms: tumor necrosis factor–alpha-308, mannose-binding lectin–221, and 3 polymorphisms in exon-1 of the mannose-binding lectin gene at codon-52, -54, and -57. Results At all gestational ages mannose-binding lectin codon-54 increased the risk of the development of diplegia (homozygous or heterozygous odds ratio, 1.55; 95% CI, 1.03-2.32). For babies who were born at term, the risk of the development of quadriplegia was associated with heterozygous tumor necrosis factor– α (odds ratio, 1.82; 95% CI, 1.04-3.15), and mannose-binding lectin codon-54 was associated with diplegia (homozygous or heterozygous odds ratio, 2.12; 95% CI, 1.10-4.05). The presence of any polymorphism in mannose-binding lectin exon–1 at term approximately doubled the risk of the development of diplegia (odds ratio, 1.94; 95% CI, 1.05-3.62). Homozygous or heterozygous tumor necrosis factor– α was associated with hemiplegia for babies who were born at <32 weeks of gestation (odds ratio, 2.38; 95% CI, 1.02-5.58). Overall, the presence of any cytokine polymorphism was associated with cerebral palsy (odds ratio, 1.37; 95% CI, 1.02-1.84). Conclusion Carriage of polymorphisms in the tumor necrosis factor– α and mannose-binding lectin genes are associated with an increased risk of cerebral palsy.
dc.description.statementofresponsibilityCatherine S. Gibson, Alastair H. MacLennan, Paul N. Goldwater, Eric A. Haan, Kevin Priest, Gustaaf A. Dekker
dc.description.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/623277/description#description
dc.identifier.citationAmerican Journal of Obstetrics and Gynecology, 2006; 194(3):674e1-674e11
dc.identifier.doi10.1016/j.ajog.2006.01.093
dc.identifier.issn0002-9378
dc.identifier.issn1097-6868
dc.identifier.orcidGoldwater, P. [0000-0003-4822-8488]
dc.identifier.orcidHaan, E. [0000-0002-7310-5124]
dc.identifier.orcidDekker, G. [0000-0002-7362-6683]
dc.identifier.orcidHague, W. [0000-0002-5355-2955]
dc.identifier.urihttp://hdl.handle.net/2440/23150
dc.language.isoen
dc.publisherMosby Inc
dc.source.urihttps://doi.org/10.1016/j.ajog.2006.01.093
dc.subjectCerebral palsy
dc.subjectTumor necrosis factor–α
dc.subjectMannose-binding lectin
dc.subjectPolymorphism
dc.titleThe association between inherited cytokine polymorphisms and cerebral palsy
dc.typeJournal article
pubs.publication-statusPublished

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