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Surface-assisted laser desorption/ionization mass spectrometry using ordered silicon nanopillar arrays

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dc.contributor.authorAlhmoud, H.Z.
dc.contributor.authorGuinan, T.M.
dc.contributor.authorElnathan, R.
dc.contributor.authorKobus, H.
dc.contributor.authorVoelcker, N.H.
dc.date.issued2014
dc.description.abstractSurface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) is ideally suited for the high-throughput analysis of small molecules in bodily fluids (e.g. saliva, urine, and blood plasma). A key application for this technique is the testing of drug consumption in the context of workplace, roadside, athlete sports and anti-addictive drug compliance. Here, we show that vertically-aligned ordered silicon nanopillar (SiNP) arrays fabricated using nanosphere lithography followed by metal-assisted chemical etching (MACE) are suitable substrates for the SALDI-MS detection of methadone and small peptides. Porosity, length and diameter are fabrication parameters that we have explored here in order to optimize analytical performance. We demonstrate the quantitative analysis of methadone in MilliQ water down to 32 ng mL−1. Finally, the capability of SiNP arrays to facilitate the detection of methadone in clinical samples is also demonstrated.
dc.identifier.citationThe Analyst, 2014; 139(22):5999-6009
dc.identifier.doi10.1039/c4an01391c
dc.identifier.issn0003-2654
dc.identifier.issn1364-5528
dc.identifier.urihttps://hdl.handle.net/1959.8/160410
dc.language.isoen
dc.publisherRSC Publications
dc.relation.fundingAlexander von Humboldt Foundation
dc.relation.fundingARC LP110200446
dc.relation.fundingForensic Science South Australia
dc.rightsCopyright 2014 The Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence: https://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/)
dc.source.urihttps://doi.org/10.1039/c4an01391c
dc.subjectlaser desorption
dc.subjectionization
dc.subjectmass spectrometry
dc.titleSurface-assisted laser desorption/ionization mass spectrometry using ordered silicon nanopillar arrays
dc.typeJournal article
pubs.publication-statusPublished
ror.fileinfo12143278090001831 13143274710001831 9915910170601831_53135394230001831.pdf
ror.mmsid9915910170601831

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