Thyrotropin releasing hormone (TRH) and lung maturation: Does 200mcg TRH provide effective stimulation to the preterm pituitary gland compared with 400mcg?

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dc.contributor.authorCrowther, C.
dc.contributor.authorHaslam, R.
dc.contributor.authorHiller, J.
dc.contributor.authorMcGee, T.
dc.contributor.authorRyall, R.
dc.contributor.authorRobinson, J.
dc.date.issued1995
dc.description.abstract<h4>Objective</h4>Our purpose was to compare the response of the fetal pituitary-thyroid axis to 200 and 400 micrograms of thyrotropin-releasing hormone administered to the mother immediately before delivery with a control group.<h4>Study design</h4>A randomized controlled trial was conducted of 26 women at gestational ages between 24 weeks and 33 weeks 6 days who had received one or more doses of betamethasone who were expected to be delivered within 1 to 4 hours. Women received either 200 or 400 micrograms of thyrotropin-releasing hormone or were in the control group.<h4>Results</h4>Thyroid-stimulating hormone determinations on cord blood had a higher mean level in both treatment groups compared with the control group. No differences were seen in cord blood results between the two treatment groups for thyroid-stimulating hormone, thyroxine, triiodothyronine, free thyroxine, free triiodothyronine, and prolactin levels. The only other differences found were in a higher level in total thyroxine and a lower level of free thyroxine in the 400 micrograms thyrotropin-releasing hormone group compared with the 200 micrograms group in the 48-hour blood determinations.<h4>Conclusion</h4>Both 200 and 400 micrograms of thyrotropin-releasing hormone provided fetal pituitary stimulation, as reflected in fetal thyroid-stimulating hormone levels in cord blood, and both gave significantly higher levels compared with a control group.
dc.description.statementofresponsibilityCaroline Crowther, Ross Haslam, Janet Hiller, Terry McGee, Richard Ryall, Jeffrey Robinson
dc.identifier.citationAmerican Journal of Obstetrics and Gynecology, 1995; 173(1):719-733
dc.identifier.doi10.1016/0002-9378(95)90329-1
dc.identifier.issn0002-9378
dc.identifier.issn1097-6868
dc.identifier.orcidCrowther, C. [0000-0002-9079-4451]
dc.identifier.orcidHiller, J. [0000-0002-8532-4033]
dc.identifier.orcidRobinson, J. [0000-0002-4515-6039]
dc.identifier.urihttp://hdl.handle.net/2440/7909
dc.language.isoen
dc.publisherC.V. Mosby
dc.source.urihttps://doi.org/10.1016/0002-9378(95)90329-1
dc.subjectPituitary Gland
dc.subjectFetal Blood
dc.subjectHumans
dc.subjectProlactin
dc.subjectThyrotropin
dc.subjectTriiodothyronine
dc.subjectThyroxine
dc.subjectGestational Age
dc.subjectPregnancy
dc.subjectDose-Response Relationship, Drug
dc.subjectAdult
dc.subjectFemale
dc.subjectThyrotropin-Releasing Hormone
dc.titleThyrotropin releasing hormone (TRH) and lung maturation: Does 200mcg TRH provide effective stimulation to the preterm pituitary gland compared with 400mcg?
dc.typeJournal article
pubs.publication-statusPublished

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