Interactions of N-ethylmaleimide and aluminium fluoride with GABAB receptor function in rat neocortical slices

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dc.contributor.authorOng, J.
dc.contributor.authorKerr, D.
dc.date.issued1995
dc.description.abstractInteractions of N-ethylmaleimide and aluminium fluoride (AlF - 4) with GABAB receptors have been examined using spontaneously discharging rat neocortical slices. The suppression of discharges by the GABAB receptor agonist baclofen (5-10 mu M) was irreversibly prevented by N-ethylmaleimide (10-50 mu M) and its analog N-phenylmaleimide (10-50 mu M), whilst superfusion of slices with NaF (10 mM) and AlCl3 (100 mu M) to form a fluoroaluminate (AlF - 4) complex markedly potentiated the action of baclofen. The lipoxygenase inhibitors, nordihydroguaiaretic acid (10-50 mu M) and eicosatetraynoic acid (10-50 mu M) or the phospholipase A2 inhibitor bromophenacylbromide (50-100 mu M) did not affect the response to baclofen. The depressant action of baclofen is evidently mediated through G-proteins, but is not dependent on arachidonic acid metabolites.
dc.identifier.citationEuropean Journal of Pharmacology, 1995; 287(2):197-200
dc.identifier.doi10.1016/0014-2999(95)00659-1
dc.identifier.issn0014-2999
dc.identifier.issn1879-0712
dc.identifier.orcidOng, J. [0000-0002-0958-460X]
dc.identifier.urihttp://hdl.handle.net/2440/5986
dc.language.isoen
dc.publisherNorth Holland
dc.source.urihttps://doi.org/10.1016/0014-2999(95)00659-1
dc.subjectCerebral Cortex
dc.subjectAnimals
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectAluminum Compounds
dc.subjectBaclofen
dc.subjectEthylmaleimide
dc.subjectReceptors, GABA-B
dc.subjectMembrane Potentials
dc.subjectDrug Interactions
dc.subjectMale
dc.titleInteractions of N-ethylmaleimide and aluminium fluoride with GABAB receptor function in rat neocortical slices
dc.typeJournal article
pubs.publication-statusPublished

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