Programming and reproductive functioning

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dc.contributor.authorDavies, M.
dc.contributor.authorNorman, R.
dc.date.issued2002
dc.description.abstractHere, we explore the influence of fetal programming and early life exposures on lifelong reproductive health through modification of the hypothalamic–pituitary–gonadal axis. A range of programming issues are considered with examples from the literature demonstrating that environmental or nutritive exposures have a crucial role in reproductive performance, fetal growth, postnatal development and reproduction-related disease risk. We pay particular attention to recent research on associations between indicators of fetal and postnatal growth and the etiology of polycystic ovary syndrome in women. We conclude that the concept of programming can be applied to reproductive development and related health outcomes, and that the complex potential for interactions between parameters controlling fetal development and postnatal exposures invokes a need to adopt a perspective across the life course of an individual.
dc.description.statementofresponsibilityMichael J. Davies and Robert J. Norman
dc.description.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/505783/description#description
dc.identifier.citationTrends in Endocrinology and Metabolism, 2002; 13(9):386-392
dc.identifier.doi10.1016/S1043-2760(02)00691-4
dc.identifier.issn1043-2760
dc.identifier.issn1879-3061
dc.identifier.orcidDavies, M. [0000-0002-5809-7541] [0000-0003-1526-0801]
dc.identifier.orcidNorman, R. [0000-0002-3118-3896]
dc.identifier.urihttp://hdl.handle.net/2440/8528
dc.language.isoen
dc.publisherElsevier Science London
dc.source.urihttps://doi.org/10.1016/s1043-2760(02)00691-4
dc.subjectfetal
dc.subjectreproduction
dc.subjectgonadotrophin
dc.subjectprogramming
dc.subjecthuman
dc.titleProgramming and reproductive functioning
dc.typeJournal article
pubs.publication-statusPublished

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