The cardiovascular protective role of docosahexaenoic acid.

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dc.contributor.authorMcLennan, P.
dc.contributor.authorHowe, P.
dc.contributor.authorAbeywardena, M.
dc.contributor.authorMuggli, R.
dc.contributor.authorRaederstorff, D.
dc.contributor.authorMano, M.
dc.contributor.authorRayner, T.
dc.contributor.authorHead, R.
dc.date.issued1996
dc.description.abstractDietary fish oils rich in n-3 polyunsaturated fatty acids can modulate a diverse range of factors contributing to cardiovascular disease. This study examined the relative roles of eicosapentaenoic acid (20:5 n-3; EPA) and docosahexaenoic acid (22:6 n-3; DHA) which are the principal n-3 polyunsaturated fatty acids regarded as candidates for cardioprotective actions. At low dietary intakes (0.4–1.1% of energy (%en)), docosahexaenoic acid but not eicosapentaenoic acid inhibited ischaemia-induced cardiac arrhythmias. At intakes of 3.9–10.0%en, docosahexaenoic acid was more effective than eicosapentaenoic acid at retarding hypertension development in spontaneously hypertensive rats (SHR) and inhibiting thromboxane-like vasoconstrictor responses in aortas from SHR. In stroke-prone SHR with established hypertension, docosahexaenoic acid (3.9–10.0%en) retarded the development of salt-loading induced proteinuria but eicosapentaenoic acid alone was ineffective. The results demonstrate that purified n-3 polyunsaturated fatty acids mimic the cardiovascular actions of fish oils and imply that docosahexaenoic acid may be the principal active component conferring cardiovascular protection.
dc.description.statementofresponsibilityPeter McLennan, Peter Howe, Mahinda Abeywardena, Reto Muggli, Daniel Raederstorff, Mark Mano, Tim Rayner and Richard Head
dc.identifier.citationEuropean Journal of Pharmacology, 1996; 300(1-2):83-89
dc.identifier.doi10.1016/0014-2999(95)00861-6
dc.identifier.issn0014-2999
dc.identifier.issn1879-0712
dc.identifier.orcidHowe, P. [0000-0001-6546-7742]
dc.identifier.orcidHead, R. [0000-0002-1196-0926]
dc.identifier.urihttp://hdl.handle.net/2440/14441
dc.language.isoen
dc.publisherELSEVIER
dc.rights© 1996 Elsevier Science B.V
dc.source.urihttp://www.sciencedirect.com.proxy.library.adelaide.edu.au/science/article/pii/0014299995008616#
dc.subjectDietary fat
dc.subjectn-3 fatty acid
dc.subjectArrhythmia
dc.subjectBlood pressure
dc.subjectProteinuria
dc.subjectThromboxane
dc.titleThe cardiovascular protective role of docosahexaenoic acid.
dc.typeJournal article
pubs.publication-statusPublished

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