Fetal growth restriction: adaptations and consequences

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dc.contributor.authorMcMillen, I.
dc.contributor.authorAdams, M.
dc.contributor.authorRoss, J.
dc.contributor.authorCoulter, C.
dc.contributor.authorSimonetta, G.
dc.contributor.authorOwens, J.
dc.contributor.authorRobinson, J.
dc.contributor.authorEdwards, L.
dc.date.issued2001
dc.descriptionCopyright © 2001 Society for Reproduction and Fertility
dc.description.abstractA range of pathophysiological factors can result in a perturbation or restriction of fetal growth, and the cardiovascular, neuroendocrine and metabolic adaptations of the fetus to these stimuli will depend on their nature, timing and intensity. The critical importance of these physiological adaptations for both immediate survival and long-term health outcomes has provided an impetus for experimental studies of the nature and consequences of specific fetal adaptations to a poor intrauterine environment. This review summarizes data from recent studies that have focused on the responses of the fetal cardiovascular, sympathoadrenal, hypothalamo-pituitary-adrenal and renin-angiotensin systems to experimental restriction of placental function in the sheep and discusses the consequences of these adaptations for fetal, neonatal and adult health.
dc.description.statementofresponsibilityI.C. McMillen, M.B. Adams, J.T. Ross, C.L. Coulter, G. Simonetta, J.A. Owens, J.S. Robinson and L.J. Edwards
dc.identifier.citationReproduction, 2001; 122(2):195-204
dc.identifier.doi10.1530/rep.0.1220195
dc.identifier.issn1470-1626
dc.identifier.issn1741-7899
dc.identifier.orcidRoss, J. [0000-0001-7243-1051]
dc.identifier.orcidOwens, J. [0000-0002-7498-1353]
dc.identifier.orcidRobinson, J. [0000-0002-4515-6039]
dc.identifier.urihttp://hdl.handle.net/2440/12003
dc.language.isoen
dc.publisherJournals of Reproduction Fertility Ltd
dc.source.urihttps://doi.org/10.1530/rep.0.1220195
dc.subjectAdrenal Glands
dc.subjectPituitary Gland
dc.subjectCardiovascular System
dc.subjectHypothalamus
dc.subjectSympathetic Nervous System
dc.subjectPlacenta
dc.subjectAnimals
dc.subjectHumans
dc.subjectFetal Growth Retardation
dc.subjectGlucocorticoids
dc.subjectAdaptation, Physiological
dc.subjectRenin-Angiotensin System
dc.subjectPregnancy
dc.subjectFemale
dc.titleFetal growth restriction: adaptations and consequences
dc.typeJournal article
pubs.publication-statusPublished

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