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Neurotrophin receptor p75 mRNA level in peripheral blood cells of patients with Alzheimer's disease

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dc.contributor.authorXu, Y.
dc.contributor.authorLi, W.W.
dc.contributor.authorWang, J.
dc.contributor.authorZhu, C.
dc.contributor.authorShen, Y.Y.
dc.contributor.authorShi, A.Y.
dc.contributor.authorZeng, G.H.
dc.contributor.authorXu, Z.Q.
dc.contributor.authorZhou, X.F.
dc.contributor.authorWang, Y.J.
dc.date.issued2019
dc.description.abstractThe neurotrophin receptor p75 (p75NTR) plays important roles in regulating amyloid-beta (Aβ) metabolism in the brain. The expression of p75NTR is altered in the brain of patients with Alzheimer's disease (AD). In this study, we aimed to evaluate whether p75NTR mRNA level in the peripheral blood cells is changed among AD patients and its potential to be a biomarker for AD. The study subjects included 26 patients with AD (PiB-PET positive) and 28 cognitively normal controls (PiB-PET negative). RNA was extracted from peripheral blood cells of fast blood. p75NTR mRNA was measured using quantitative real-time PCR assay. p75NTR mRNA levels in blood cells were comparable between AD patients and controls. p75NTR mRNA levels in blood cells were not correlated with MMSE scores, ApoE genotypes, gender, and age. p75NTR mRNA expression in blood cells is not changed in AD patients and is unlikely to be a biomarker for AD
dc.identifier.citationNeurotoxicity Research, 2019; 36(1):101-107
dc.identifier.doi10.1007/s12640-019-00035-9
dc.identifier.issn1029-8428
dc.identifier.issn1476-3524
dc.identifier.orcidZhou, X.F. [0000-0002-8687-0175]
dc.identifier.urihttps://hdl.handle.net/11541.2/136929
dc.language.isoen
dc.publisherSpringer
dc.rightsCopyright 2019 Springer
dc.source.urihttps://doi.org/10.1007/s12640-019-00035-9
dc.subjectAlzheimer's disease (AD)
dc.subjectmRNA
dc.subjectp75 neurotrophin receptor (p75NTR)
dc.subjectPittsburgh compound B (PiB)
dc.subjectHumans
dc.subjectAlzheimer Disease
dc.subjectApolipoproteins E
dc.subjectReceptors, Nerve Growth Factor
dc.subjectNerve Tissue Proteins
dc.subjectRNA, Messenger
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectBiomarkers
dc.titleNeurotrophin receptor p75 mRNA level in peripheral blood cells of patients with Alzheimer's disease
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9916279039501831

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