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Virulence of Streptococcus pneumoniae: PsaA mutants are hypersensitive to oxidative stress

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dc.contributor.authorTseng, H.
dc.contributor.authorMcEwan, A.
dc.contributor.authorPaton, J.
dc.contributor.authorJennings, M.
dc.date.issued2002
dc.descriptionCopyright © 2002, American Society for Microbiology. All Rights Reserved.
dc.description.abstractpsaA encodes a 37-kDa pneumococcal lipoprotein which is part of an ABC Mn(II) transport complex. Streptococcus pneumoniae D39 psaA mutants have previously been shown to be significantly less virulent than wild-type D39, but the mechanism underlying the attenuation has not been resolved. In this study, we have shown that psaA and psaD mutants are highly sensitive to oxidative stress, i.e., to superoxide and hydrogen peroxide, which might explain why they are less virulent than the wild-type strain. Our investigations revealed altered expression of the key oxidative-stress response enzymes superoxide dismutase and NADH oxidase in psaA and psaD mutants, suggesting that PsaA and PsaD may play important roles in the regulation of expression of oxidative-stress response enzymes and intracellular redox homeostasis.
dc.description.statementofresponsibilityHsing-Ju Tseng, Alastair G. McEwan, James C. Paton, and Michael P. Jennings
dc.description.urihttp://iai.asm.org/content/vol70/issue10/index.dtl
dc.identifier.citationInfection and Immunity, 2002; 70(3):1635-1639
dc.identifier.doi10.1128/IAI.70.3.1635-1639.2002
dc.identifier.issn0019-9567
dc.identifier.issn1098-5522
dc.identifier.orcidPaton, J. [0000-0001-9807-5278]
dc.identifier.urihttp://hdl.handle.net/2440/28199
dc.language.isoen
dc.publisherAmer Soc Microbiology
dc.source.urihttps://doi.org/10.1128/iai.70.3.1635-1639.2002
dc.subjectStreptococcus pneumoniae
dc.subjectHydrogen Peroxide
dc.subjectCations, Divalent
dc.subjectManganese
dc.subjectParaquat
dc.subjectMultienzyme Complexes
dc.subjectNADH, NADPH Oxidoreductases
dc.subjectSuperoxide Dismutase
dc.subjectLipoproteins
dc.subjectBacterial Proteins
dc.subjectAdhesins, Bacterial
dc.subjectCarrier Proteins
dc.subjectMembrane Transport Proteins
dc.subjectOxidative Stress
dc.subjectMutation
dc.titleVirulence of Streptococcus pneumoniae: PsaA mutants are hypersensitive to oxidative stress
dc.typeJournal article
pubs.publication-statusPublished

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