Sensing Intra- and Extra-Cellular Ca2+ in the Islet of Langerhans
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Date
2022
Authors
Huang, W.
Wu, T.
Xie, C.
Rayner, C.K.
Priest, C.
Ebendorff-Heidepriem, H.
Zhao, J.
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Journal article
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Advanced Functional Materials, 2022; 32(3):1-24
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Abstract
Calcium ions (Ca²⁺) take part in intra- and inter-cellular signaling to mediate cellular functions. Sensing this ubiquitous messenger is instrumental in disentangling the specific functions of cellular sub-compartments and/or intercellular communications. In this review, the authors first describe intra- and inter-cellular Ca²⁺ signaling in relation to insulin secretion from the pancreatic islets, and then outline the development of diverse sensors, for example, chemically synthesized indicators, genetically encoded proteins, and ion-selective microelectrodes, for intra- and extra-cellular sensing of Ca²⁺.
Particular emphasis is placed on emerging approaches in this field, such as low-affinity Ca²⁺ indicators and unique Ca²⁺-responsive composite materials. The authors conclude by remarking on the challenges and opportunities for further developments in this field, which may facilitate a more comprehensive understanding of Ca²⁺ signaling within and outside the islets, and its relevance in health and disease.
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Copyright 2021 Wiley-VCH GmbH
Access Condition Notes: Accepted manuscript available after 1 January 2023