In depth analysis of the Sox4 gene locus that consists of sense and natural antisense transcripts

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dc.contributor.authorLing, K.
dc.contributor.authorBrautigan, P.
dc.contributor.authorMoore, S.
dc.contributor.authorFraser, R.
dc.contributor.authorLeong, M.
dc.contributor.authorLeong, J.
dc.contributor.authorZainal Abidin, S.
dc.contributor.authorLee, H.
dc.contributor.authorCheah, P.
dc.contributor.authorRaison, J.
dc.contributor.authorBabic, M.
dc.contributor.authorLee, Y.
dc.contributor.authorDaish, T.
dc.contributor.authorMattiske, D.
dc.contributor.authorMann, J.
dc.contributor.authorAdelson, D.
dc.contributor.authorThomas, P.
dc.contributor.authorHahn, C.
dc.contributor.authorScott, H.
dc.date.issued2016
dc.descriptionAvailable online 17 February 2016
dc.description.abstractSRY (Sex Determining Region Y)-Box 4 or Sox4 is an important regulator of the pan-neuronal gene expression during post-mitotic cell differentiation within the mammalian brain. Sox4 gene locus has been previously characterized with multiple sense and overlapping natural antisense transcripts [1], [2]. Here we provide accompanying data on various analyses performed and described in Ling et al. [2]. The data include a detail description of various features found at Sox4 gene locus, additional experimental data derived from RNA-Fluorescence in situ Hybridization (RNA-FISH), Western blotting, strand-specific reverse-transcription quantitative polymerase chain reaction (RT-qPCR), gain-of-function and in situ hybridization (ISH) experiments. All the additional data provided here support the existence of an endogenous small interfering- or PIWI interacting-like small RNA known as Sox4_sir3, which origin was found within the overlapping region consisting of a sense and a natural antisense transcript known as Sox4ot1.
dc.description.statementofresponsibilityKing-Hwa Ling, Peter J. Brautigan, Sarah Moore, Rachel Fraser, Melody Pui-Yee Leong, Jia-Wen Leong, Shahidee Zainal Abidin, Han-Chung Lee, Pike-See Cheah, Joy M. Raison, Milena Babic, Young Kyung Lee, Tasman Daish, Deidre M. Mattiske, Jeffrey R. Mann, David L. Adelson, Paul Q. Thomas, Christopher N. Hahn, Hamish S.Scott
dc.identifier.citationData in Brief, 2016; 7:282-290
dc.identifier.doi10.1016/j.dib.2016.01.045
dc.identifier.issn2352-3409
dc.identifier.issn2352-3409
dc.identifier.orcidAdelson, D. [0000-0003-2404-5636]
dc.identifier.orcidHahn, C. [0000-0001-5105-2554]
dc.identifier.orcidScott, H. [0000-0002-5813-631X]
dc.identifier.urihttp://hdl.handle.net/2440/106762
dc.language.isoen
dc.publisherElsevier
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/171601
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/461204
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/219176
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/257501
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/257529
dc.rights© 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
dc.source.urihttps://doi.org/10.1016/j.dib.2016.01.045
dc.subjectEndogenous siRNA
dc.subjectBrain development
dc.subjectNatural antisense transcripts
dc.titleIn depth analysis of the Sox4 gene locus that consists of sense and natural antisense transcripts
dc.typeJournal article
pubs.publication-statusPublished

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