Expression of Bcl-xL and Mcl-1 in the nonmelanoma skin cancers of renal transplant recipients
Date
2015
Authors
Burke, M.
Morais, C.
Oliver, K.
Lambie, D.
Gobe, G.
Carroll, R.
Staatz, C.
Sinnya, S.
Soyer, H.
Winterford, C.
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Journal article
Citation
American Journal of Clinical Pathology, 2015; 143(4):514-526
Statement of Responsibility
Michael T. Burke, Christudas Morais, Kimberley A. Oliver, Duncan L. J. Lambie, Glenda C. Gobe, Robert P. Carroll, Christine E. Staatz, Sudipta Sinnya, H. Peter Soyer, Clay Winterford, Nikolas K. Haass, Scott B. Campbell and Nicole M. Isbel
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Abstract
Objectives: This study aims to investigate how immunosuppression influences the protein expression of antiapoptotic members of the Bcl-2 family—namely, Bcl-xL and Mcl-1—in nonmelanoma skin cancer (NMSC) and the peritumoral epidermis of renal transplant recipients. Methods: NMSC and peritumoral epidermis protein expression of Bcl-xL and Mcl-1 were assessed by immunohistochemistry in renal transplant recipients receiving tacrolimus or sirolimus and the general population not receiving immunosuppression. Results: NMSC from renal transplant recipients compared with patients not receiving immunosuppressant medications had a reduced Bcl-xL expression intensity (P = .042). Mcl-1 expression intensity in NMSC was decreased in tacrolimus-treated patients compared with sirolimus-treated patients and the nonimmunosuppressed population (P = .024). Bcl-xL expression intensity was increased in peritumoral epidermis compared with NMSC (P = .002). Conclusions: It was shown for the first time that Bcl-xL and Mcl-1 expression are widespread in the peritumoral epidermis and NMSC of renal transplant recipients. Importantly in NMSC, Bcl-xL expression was reduced with immunosuppression exposure, and Mcl-1 expression was reduced in tacrolimus-treated compared with sirolimustreated patients.
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© 2015 by The American Society for Clinical Pathology