Syndrome of inappropriate antidiuretic hormone secretion associated with desvenlafaxine
Date
2013
Authors
Liew, E.D.
Alderman, C.P.
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Journal article
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International Journal of Clinical Pharmacy, 2013; 36(2):253-255
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Abstract
Objective: To report a case of syndrome of inappropriate anti-diuretic hormone (SIADH) secretion associated with desvenlafaxine.
Case summary: A 57-yearold female with hyponatraemia. Her medications included desvenlafaxine, and symptoms included nausea, anxiety and confusion. The serum sodium at this time was 120 mmol/L, serum osmolality was 263 mosmol/kg, urine osmolality 410 mosmol/kg and urine sodium 63 mmol/L, consistent with a diagnosis of SIADH. Desvenlafaxine was ceased and fluid restriction implemented. After 4 days the sodium increased to 128 mmol/L and fluid restriction was relaxed. During her further 3 weeks inpatient admission the serum sodium ranged from 134 to 137 mmol/L during treatment with mirtazapine.
Discussion: SIADH has been widely reported with a range of antidepressants. This case report suggests that desvenlafaxine might cause clinically significant hyponatremia.
Conclusions: Clinicians should be aware of the potential for antidepressants to cause hyponatremia, and take appropriate corrective action where necessary.
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Copyright 2013 Koninklijke Nederlandse Maatschappij ter bevordering der Pharmacie