The sheep genome illuminates biology of the rumen and lipid metabolism

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dc.contributor.authorJiang, Y.
dc.contributor.authorXie, M.
dc.contributor.authorChen, W.
dc.contributor.authorTalbot, R.
dc.contributor.authorMaddox, J.
dc.contributor.authorFaraut, T.
dc.contributor.authorWu, C.
dc.contributor.authorMuzny, D.
dc.contributor.authorLi, Y.
dc.contributor.authorZhang, W.
dc.contributor.authorStanton, J.
dc.contributor.authorBrauning, R.
dc.contributor.authorBarris, W.
dc.contributor.authorHourlier, T.
dc.contributor.authorAken, B.
dc.contributor.authorSearle, S.
dc.contributor.authorAdelson, D.
dc.contributor.authorBian, C.
dc.contributor.authorCam, G.
dc.contributor.authorChen, Y.
dc.contributor.authoret al.
dc.date.issued2014
dc.description.abstractSheep (Ovis aries) are a major source of meat, milk, and fiber in the form of wool and represent a distinct class of animals that have a specialized digestive organ, the rumen, that carries out the initial digestion of plant material. We have developed and analyzed a high-quality reference sheep genome and transcriptomes from 40 different tissues. We identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. We also identified genes involved in lipid metabolism that had been amplified and/or had altered tissue expression patterns. This may be in response to changes in the barrier lipids of the skin, an interaction between lipid metabolism and wool synthesis, and an increased role of volatile fatty acids in ruminants compared with nonruminant animals.
dc.description.statementofresponsibilityYu Jiang ... David L. Adelson ... et al.
dc.identifier.citationScience, 2014; 344(6188):1168-1173
dc.identifier.doi10.1126/science.1252806
dc.identifier.issn0036-8075
dc.identifier.issn1095-9203
dc.identifier.orcidAdelson, D. [0000-0003-2404-5636]
dc.identifier.urihttp://hdl.handle.net/2440/89962
dc.language.isoen
dc.publisherAmerican Association for the Advancement of Science
dc.rights© 2014 American Association for the Advancement of Science. All Rights Reserved.
dc.source.urihttps://doi.org/10.1126/science.1252806
dc.subjectRumen
dc.subjectFatty Acids, Volatile
dc.subjectPhylogeny
dc.subjectGene Expression Regulation
dc.subjectAmino Acid Sequence
dc.subjectMolecular Sequence Data
dc.subjectLipid Metabolism
dc.subjectKeratins, Hair-Specific
dc.subjectGenome
dc.subjectTranscriptome
dc.subjectSheep, Domestic
dc.titleThe sheep genome illuminates biology of the rumen and lipid metabolism
dc.typeJournal article
pubs.publication-statusPublished

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