Biological actions of antibacterial compounds covalently attached onto solid material surfaces or released diffusively from materials /
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(Published version)
Date
2016
Authors
Mon, Htwe Htwe,
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thesis
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Abstract
Bacterial biofilms are aggregates of microorganisms that are responsible for numerous persistent infections and fouling problems, and are difficult to treat. There is a pressing need for new materials that can resist biofilm contamination associated with implanted medical devices. There is also a need for new antibiofilm pharmaceuticals that can effect dispersion and removal of established biofilms, which are problematic in chronic infected wounds. This PhD thesis work has involved investigation of approaches for the prevention of biofilm formation at biomaterials/biomedical devices surfaces, approaches which fall into the categories of covalently grafted drugs or drugs being released from bulk materials. Particular emphasis is placed on plasma polymerisation technology, as this coating method is transferable between a large range of different materials and hence can be applied to a variety of biomedical devices and implants without the need for specific substrates. This study included both known, clinically used antibiotics as well as a novel antimicrobial serrulatane compound (8-hydroxyserrulat-14-en-19-oic acid – denoted EN4) derived from the native Australian plant Eremophila neglecta, which was used to study biofilm breakup activity.
School/Discipline
University of South Australia. Sansom Institute for Health Research.
Sansom Institute for Health Research.
Sansom Institute for Health Research.
Dissertation Note
Thesis (PhD(Medical Science))--University of South Australia, 2016.
Provenance
Copyright 2016 Htwe Mon.
Description
1 ethesis (iv, 252 pages) :
illustrations (some colour), maps.
Includes bibliographical references (pages 212-236)
illustrations (some colour), maps.
Includes bibliographical references (pages 212-236)
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506 0#$fstar $2Unrestricted online access