Fabrication and properties of porous scaffold of zein/PCL biocomposite for bone tissue engineering

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dc.contributor.authorWu, F.
dc.contributor.authorWei, J.
dc.contributor.authorLiu, C.
dc.contributor.authorO'Neill, B.
dc.contributor.authorNgothai, Y.
dc.date.issued2012
dc.description.abstractThe aim of this study was to fabricate porous scaffolds of zein/poly(-caprolactone) (PCL) biocomposite by solvent casting-particulate leaching method using sodium chloride particles as the porogen. Porous biocomposite scaffolds with porosity around 70% and well-interconnected network were obtained. The incorporation of zein into PCL led to the improvement of hydrophilicity as indicated by the results of water contact angle measurement. After immersion in phosphate buffered saline (PBS) in vitro for 28 days, it was observed that the degradation rate of the zein/PCL biocomposite scaffold was faster than the PCL scaffold and that the rate could be tailored by adjusting the amount of zein in the composite. The results demonstrate the potential of the zein/PCL biocomposite scaffolds to be used in tissue engineering strategies to regenerate bone defects. © 2012 Elsevier Ltd. All rights reserved.
dc.description.statementofresponsibilityFan Wu, Jie Wei, Changsheng Liu, Brian O’Neill, Yung Ngothai
dc.identifier.citationComposites Part B: Engineering, 2012; 43(5):2192-2197
dc.identifier.doi10.1016/j.compositesb.2012.02.040
dc.identifier.issn1359-8368
dc.identifier.issn1879-1069
dc.identifier.orcidNgothai, Y. [0000-0002-0199-4225]
dc.identifier.urihttp://hdl.handle.net/2440/73041
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.rightsCopyright © 2012 Elsevier Ltd. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.compositesb.2012.02.040
dc.subjectB. Microstructures
dc.subjectB. Porosity
dc.subjectB. Wettability
dc.subjectBiocomposite scaffold
dc.titleFabrication and properties of porous scaffold of zein/PCL biocomposite for bone tissue engineering
dc.typeJournal article
pubs.publication-statusPublished

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