Effect of nitric oxide synthase inhibitors on short-term appetite and food intake in humans

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dc.contributor.authorVozzo, R.
dc.contributor.authorWittert, G.
dc.contributor.authorHorowitz, M.
dc.contributor.authorMorley, J.
dc.contributor.authorChapman, I.
dc.date.issued1999
dc.description.abstractAnimal studies suggest that nitric oxide (NO) may be a physiological regulator of appetite; NO synthase (NOS) inhibition suppresses food intake in rats, mice, and chickens. It is not known whether NO has any effect on appetite in humans. We have usedN G-monomethyl-l-arginine (l-NMMA) andN G-nitro-l-arginine methyl ester (l-NAME), both competitive, nonselective inhibitors of NOS, in two separate studies to evaluate the role of NO in the short-term regulation of appetite in humans. Instudy I, 13 men (18–25 yr) underwent paired studies, in randomized, double-blind fashion, after an overnight fast. l-NMMA (4 mg ⋅ kg−1 ⋅ h−1) or saline (0.9%) was infused intravenously at a rate of 40 ml/h for 1.5 h. In study II, eight men (18–26 yr) underwent three randomized, double-blind studies after an overnight fast. l-NAME (75 or 180 μg ⋅ kg−1 ⋅ h−1) or saline (0.9%) was infused intravenously at a rate of 20 ml/h for 120 min. Hunger and fullness were measured using visual analog scales; blood pressure and heart rate were monitored, and 30 min before the end of the infusion, subjects were offered a cold buffet meal. Total caloric intake and the macronutrient composition of the meal were determined. Both l-NMMA (P = 0.052) andl-NAME (P < 0.05; both doses) decreased heart rate, l-NMMA increased diastolic blood pressure (P < 0.01), and l-NAME increased systolic blood pressure (P = 0.052). Neither drug had any effect on caloric intake or sensations of hunger or fullness. Despite having significant effects on cardiovascular function in the doses used, neitherl-NMMA norl-NAME had any effect on feeding, suggesting that NO does not affect short-term appetite or food intake in humans.
dc.description.statementofresponsibilityRosalie Vozzo, Gary A. Wittert, Michael Horowitz, John E. Morley, and Ian M. Chapman
dc.identifier.citationAmerican Journal of Physiology. Regulatory Integrative and Comparative Physiology, 1999; 276(6):R1562-R1568
dc.identifier.doi10.1152/ajpregu.1999.276.6.r1562
dc.identifier.issn0363-6119
dc.identifier.issn1522-1490
dc.identifier.orcidWittert, G. [0000-0001-6818-6065]
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]
dc.identifier.orcidMorley, J. [0000-0001-6444-2965]
dc.identifier.urihttp://hdl.handle.net/2440/8595
dc.language.isoen
dc.publisherAmerican Physiological Society
dc.rightsCopyright © 1999 the American Physiological Society
dc.source.urihttp://ajpregu.physiology.org/content/276/6/R1562
dc.subjectHumans
dc.subjectNG-Nitroarginine Methyl Ester
dc.subjectomega-N-Methylarginine
dc.subjectEnzyme Inhibitors
dc.subjectDouble-Blind Method
dc.subjectHunger
dc.subjectAppetite
dc.subjectSatiety Response
dc.subjectBlood Pressure
dc.subjectHeart Rate
dc.subjectEating
dc.subjectAdolescent
dc.subjectAdult
dc.subjectMale
dc.subjectNitric Oxide Synthase
dc.titleEffect of nitric oxide synthase inhibitors on short-term appetite and food intake in humans
dc.typeJournal article
pubs.publication-statusPublished

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