The genome sequence of Taurine cattle: a window to ruminant biology and evolution

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dc.contributor.authorBovine Genome Sequencing and Analysis Consortium,
dc.contributor.authorElsik, C.
dc.contributor.authorTellam, R.
dc.contributor.authorWorley, K.
dc.contributor.otherAdelson, David Louis
dc.date.issued2009
dc.descriptionDavid L. Adelson is a member of The Bovine Genome Sequencing and Analysis Consortium.
dc.description.abstractTo understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
dc.description.statementofresponsibilityThe Bovine Genome Sequencing and Analysis Consortium, Christine G. Elsik, Ross L. Tellam, Kim C. Worley
dc.identifier.citationScience, 2009; 324(5926):522-528
dc.identifier.doi10.1126/science.1169588
dc.identifier.issn0036-8075
dc.identifier.issn1095-9203
dc.identifier.urihttp://hdl.handle.net/2440/57272
dc.language.isoen
dc.publisherAmerican Association for the Advancement of Science
dc.rightsCopyright 2009 by the American Association for the Advancement of Science; all rights reserved.
dc.source.urihttps://doi.org/10.1126/science.1169588
dc.subjectBovine Genome Sequencing and Analysis Consortium
dc.subjectAnimals
dc.subjectAnimals, Domestic
dc.subjectCattle
dc.subjectHumans
dc.subjectProteins
dc.subjectMicroRNAs
dc.subjectSequence Analysis, DNA
dc.subjectEvolution, Molecular
dc.subjectSpecies Specificity
dc.subjectAlternative Splicing
dc.subjectSynteny
dc.subjectGenome
dc.subjectMolecular Sequence Data
dc.subjectFemale
dc.subjectMale
dc.subjectGenetic Variation
dc.subjectBiological Evolution
dc.titleThe genome sequence of Taurine cattle: a window to ruminant biology and evolution
dc.typeJournal article
pubs.publication-statusPublished

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