In utero Programming of Allergic Susceptibility

Simple item page
dc.contributor.authorGrieger, J.
dc.contributor.authorClifton, V.
dc.contributor.authorTuck, A.
dc.contributor.authorWooldridge, A.
dc.contributor.authorRobertson, S.
dc.contributor.authorGatford, K.
dc.date.issued2016
dc.description.abstractBackground: Around 30-40% of the world's population will experience allergy, the most common and earliest-onset noncommunicable disease. With a steady rise in the incidence of allergic disease over recent decades, up to 18% of children will suffer a respiratory, food or skin allergy before their 18th birthday. There is compelling evidence that the risk of developing allergy is influenced by early life events and particularly in utero exposures. Methods: A comprehensive literature review was undertaken which outlines prenatal risk factors and potential mechanisms underlying the development of allergy in childhood. Results: Exposures including maternal cigarette smoking, preterm birth and Caesarean delivery are implicated in predisposing infants to the later development of allergy. In contrast, restricted growth in utero, a healthy maternal diet and a larger family size are protective, but the mechanisms here are unclear and require further investigation. Conclusion: To ameliorate the allergy pandemic in young children, we must define prenatal mechanisms that alter the programming of the fetal immune system and also identify specific targets for antenatal interventions.
dc.description.statementofresponsibilityJessica A. Grieger, Vicki L. Clifton, Astrud R. Tuck, Amy L. Wooldridge, Sarah A. Robertson, Kathryn L. Gatford
dc.identifier.citationInternational Archives of Allergy and Immunology, 2016; 169(2):80-92
dc.identifier.doi10.1159/000443961
dc.identifier.issn1018-2438
dc.identifier.issn1423-0097
dc.identifier.orcidGrieger, J. [0000-0003-1515-948X]
dc.identifier.orcidClifton, V. [0000-0002-4892-6748]
dc.identifier.orcidWooldridge, A. [0000-0002-2914-7693]
dc.identifier.orcidRobertson, S. [0000-0002-9967-0084]
dc.identifier.orcidGatford, K. [0000-0002-2823-3004]
dc.identifier.urihttp://hdl.handle.net/2440/99739
dc.language.isoen
dc.publisherKarger
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1041918
dc.rights© 2016 S. Karger AG, Basel
dc.source.urihttps://doi.org/10.1159/000443961
dc.subjectPlacenta
dc.subjectAnimals
dc.subjectHumans
dc.subjectPrenatal Exposure Delayed Effects
dc.subjectHypersensitivity
dc.subjectDisease Susceptibility
dc.subjectDiet
dc.subjectRisk Factors
dc.subjectMaternal Exposure
dc.subjectImmunity, Maternally-Acquired
dc.subjectDNA Methylation
dc.subjectEpigenesis, Genetic
dc.subjectPregnancy
dc.subjectDietary Supplements
dc.subjectInfant, Newborn
dc.subjectFemale
dc.titleIn utero Programming of Allergic Susceptibility
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Obstetrics and Gynaecology publications