Herpes simplex virus infection of murine sensory ganglia induces proliferation of neuronal satellite cells

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dc.contributor.authorElson, Karenen
dc.contributor.authorSpeck, Peter Geralden
dc.contributor.authorSimmons, Anthonyen
dc.contributor.schoolSchool of Medical Sciences : Pathologyen
dc.date.issued2003en
dc.description© 2003 Society for General Microbiologyen
dc.description.abstractHerpes simplex virus (HSV) is a virtually ubiquitous human pathogen that, following cutaneous infection, latently infects neurons of sensory ganglia. Satellite cells (SCs) ensheath and provide metabolic support for these neurons, and could potentially participate in controlling HSV disease. Although SCs are restrictive for HSV replication, hypercellularity of non-neuronal cells in ganglia is prominent during HSV infection in animal models. SCs proliferate in response to trauma, e.g. nerve cut or crush, but it is not known if proliferation occurs in response to viral infection. To address this issue, cell proliferation, measured by bromodeoxyuridine (BrdU) uptake, and immune infiltrate, measured by CD45 labelling, were examined during acute infection in a mouse model. Because SCs do not express CD45, the BrdU⁺ CD45⁻ cell subset represents the proliferating SC population. We report that during acute ganglionic HSV infection there is a substantial increase in SC numbers. We suggest that SC proliferation in response to HSV infection may occur in order to facilitate neuronal survival.en
dc.description.statementofresponsibilityKaren Elson, Peter Speck and Anthony Simmonsen
dc.identifier.citationJournal of General Virology, 2003; 84:1079-1084en
dc.identifier.doi10.1099/vir.0.19035-0en
dc.identifier.issn0022-1317en
dc.identifier.urihttp://hdl.handle.net/2440/55384
dc.language.isoenen
dc.publisherSoc General Microbiologyen
dc.titleHerpes simplex virus infection of murine sensory ganglia induces proliferation of neuronal satellite cellsen
dc.typeJournal articleen

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