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Hydrogel scaffolds: Advanced materials for soft tissue re-growth

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dc.contributor.authorAbdul Hamid, Z.A.
dc.contributor.authorBlencowe, A.
dc.contributor.authorPalmer, J.
dc.contributor.authorAbberton, K.M.
dc.contributor.authorMorrison, W.A.
dc.contributor.authorPenington, A.J.
dc.contributor.authorQiao, G.G.
dc.contributor.authorStevens, G.
dc.contributor.conference5th Kuala Lumpur International Conference on Biomedical Engineering (BIOMED 2011) (20 Jun 2011 - 23 Jun 2011 : MALAYSIA, Kuala Lumpur)
dc.contributor.editorAbuOsman, N.A.
dc.contributor.editorAbas, W.A.W.
dc.contributor.editorAbdulWahab, A.K.
dc.contributor.editorTing, H.N.
dc.date.issued2011
dc.description.abstractHydrogels have been extensively investigated for use in tissue engineering applications as a result of their unique characteristics, including their hydrophilic nature, high affinity for water and characteristic macromolecular gel structure. In this study we have successfully synthesised novel biodegradable hydrogel scaffolds using the diepoxide, poly(ethyleneglycol) diglycidylether (PEGDGE), and the crosslinker, cystamine. These components were then covalently cross-linked with a hydrophobic polymer that acts as 'macromolecular spring'. The incorporation of this hydrophobic ω, α-diamino polycaprolactone (PCL) secondary cross-linkers led to significant increases in the mechanical strength of the hydrogels. Fused salt templates were utilized to provide an improved interconnectivity of the resulting pores in the hydrogels. In-vivo subcutaneous implantation revealed that the covalently cross-linked hydrogel scaffolds showed enormous potential in soft tissue re-growth as a result of promising tissue regeneration and limited foreign body responses.
dc.identifier.citationIFMBE proceedings, 2011 / AbuOsman, N.A., Abas, W.A.W., AbdulWahab, A.K., Ting, H.N. (ed./s), vol.35 IFMBE, pp.831-835
dc.identifier.doi10.1007/978-3-642-21729-6_203
dc.identifier.isbn978-3-642-21728-9
dc.identifier.issn1680-0737
dc.identifier.issn1433-9277
dc.identifier.orcidBlencowe, A. [0000-0002-7630-4874]
dc.identifier.urihttps://hdl.handle.net/1959.8/154007
dc.language.isoen
dc.publisherSPRINGER
dc.publisher.placeBerlin, Germany
dc.relation.fundingSLAB Fellowship (TheMinistry of Higher Education, Malaysia and Universiti Sains Malaysia)
dc.relation.fundingMelbourne Ventures Pty Ltd
dc.relation.fundingUniversity of Melbourne Growing Innovation Fund (GIF)
dc.relation.ispartofseriesIFMBE Proceedings
dc.rightsCopyright 2011 Springer-Verlag
dc.source.urihttps://doi.org/10.1007/978-3-642-21729-6_203
dc.subjecthydrogel scaffolds
dc.subjectinvivo subcutaneous implantation
dc.subjectsoft-tissue engineering
dc.titleHydrogel scaffolds: Advanced materials for soft tissue re-growth
dc.typeConference paper
pubs.publication-statusPublished
ror.mmsid9915909157301831

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