Vitamin D in preterm infants: a prospective observational study

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dc.contributor.authorPinto, K.
dc.contributor.authorCollins, C.
dc.contributor.authorGibson, R.
dc.contributor.authorAndersen, C.
dc.date.issued2015
dc.description.abstractAIM: Preterm infants are at increased risk of vitamin D deficiency as a result of both maternal deficiency and inadequate supplementation. The quantity and effectiveness of vitamin D supplementation in preterm infants are unclear. The aim of this study was to evaluate the natural history of vitamin D status in preterm infants and the effectiveness of the hospital's nutritional practices in meeting current supplementation recommendations. METHODS: A prospective observational study was undertaken in the Neonatal Unit at the Women's and Children's Hospital, Adelaide. Enrolled infants received a standardised nutrition protocol with emphasis on vitamin D supplementation. The main outcome measure was a comparison of the proportion of vitamin D-deficient infants (25(OH)D < 50 nmol/L) at birth versus 36 weeks post-menstrual age/discharge. RESULTS: Twenty-eight infants born between 30 and 36 weeks gestation were enrolled. The proportion of vitamin D-deficient infants decreased from initial to final measurement (32.1% vs. 7.1%, P = 0.016), whereas mean (standard deviation) 25(OH)D3 increased over the same period (58.4 (18.4) vs. 82.9 (29.2) nmol/L, P < 0.001). Mean vitamin D intake was 643.6 (285.3) IU/day. CONCLUSIONS: Current nutritional practices are effective in meeting recommendations regarding vitamin D intake and result in a lower proportion of deficient infants at 36 weeks post-menstrual age/discharge.
dc.description.statementofresponsibilityKieran Pinto, Carmel T Collins, Robert A Gibson, and Chad C Andersen
dc.identifier.citationJournal of Paediatrics and Child Health, 2015; 51(7):679-681
dc.identifier.doi10.1111/jpc.12847
dc.identifier.issn1034-4810
dc.identifier.issn1440-1754
dc.identifier.orcidCollins, C. [0000-0003-3308-9948]
dc.identifier.orcidGibson, R. [0000-0002-8750-525X]
dc.identifier.orcidAndersen, C. [0000-0002-1364-4986]
dc.identifier.urihttp://hdl.handle.net/2440/89542
dc.language.isoen
dc.publisherWiley
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1046207
dc.rights© 2015 The Authors
dc.source.urihttps://doi.org/10.1111/jpc.12847
dc.subjectneonatology
dc.subjectnutrition
dc.subjectpreterm
dc.subjectvitamin D
dc.titleVitamin D in preterm infants: a prospective observational study
dc.typeJournal article
pubs.publication-statusPublished

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