The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation
Date
2013
Authors
Verweij, K.J.H.
Vinkhuyzen, A.A.E.
Benyamin, B.
Lynskey, M.T.
Quaye, L.
Agrawal, A.
Gordon, S.D.
Montgomery, G.W.
Madden, P.A.F.
Heath, A.C.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Addiction Biology, 2013; 18(5):846-850
Statement of Responsibility
Conference Name
Abstract
While initiation of cannabis use is around 40% heritable, not much is known about the underlying genetic aetiology. Here, we meta-analysed two genome-wide association studies of initiation of cannabis use with > 10 000 individuals. None of the genetic variants reached genome-wide significance. We also performed a gene-based association test, which also revealed no significant effects of individual genes. Finally, we estimated that only approximately 6% of the variation in cannabis initiation is due to common genetic variants. Future genetic studies using larger sample sizes and different methodologies (including sequencing) might provide more insight in the complex genetic aetiology of cannabis use.
School/Discipline
Dissertation Note
Provenance
Description
Link to a related website: http://europepmc.org/articles/pmc3548058?pdf=render, Open Access via Unpaywall
Access Status
Rights
Copyright 2012 The Authors