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The preparation of side chain functionalized analogues of coenzyme Q for protein conjugation studies

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dc.contributor.authorDaines, A.
dc.contributor.authorAbell, A.
dc.date.issued2004
dc.description.abstractThe synthesis of two analogues of CoQ ( 10 and 13) suitable for conjugation to a peptide or protein, and hence the development of an ELISA immunoassay, is presented. These analogues were synthesized from the protected quinone, 1-bromo-2-methyl-3,4,5,6-tetramethoxybenzene ( 1), itself prepared from commercially available CoQ-0 ( 3). Model coupling studies of one of the analogues ( 10) to N-acetyl-L-lysine methyl ester and a lysine containing dipeptide (N-acetyl-glycine-L-lysine methyl ester) were also undertaken as a first step to monoclonial antibody production.
dc.identifier.citationOrganic and Biomolecular Chemistry, 2004; 2(16):2371-2375
dc.identifier.doi10.1039/b407659a
dc.identifier.issn1477-0520
dc.identifier.issn1477-0539
dc.identifier.orcidAbell, A. [0000-0002-0604-2629]
dc.identifier.urihttp://hdl.handle.net/2440/34859
dc.language.isoen
dc.publisherRoyal Soc Chemistry
dc.source.urihttps://doi.org/10.1039/b407659a
dc.subjectUbiquinone
dc.subjectProteins
dc.subjectMolecular Structure
dc.subjectProtein Binding
dc.titleThe preparation of side chain functionalized analogues of coenzyme Q for protein conjugation studies
dc.typeJournal article
pubs.publication-statusPublished

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