Carbon catabolite repression in Aspergillus nidulans involves deubiquitination

Simple item page
dc.contributor.authorLockington, R.
dc.contributor.authorKelly, J.
dc.date.issued2001
dc.descriptionThe definitive version is available at www.blackwell-synergy.com
dc.description.abstractThe best studied role of ubiquitination is to mark proteins for destruction by the proteasome but, in addition, it has recently been shown to promote macromolecular assembly and function, and alter protein function, thus playing a regulatory role distinct from protein degradation. Deubiquinating enzymes, the ubiquitin-processing proteases (ubps) and the ubiquitin carboxy-terminal hydrolases (uchs), remove ubiquitin from ubiquitinated substrates. We show here that the creB gene involved in carbon catabolite repression in Aspergillus nidulans encodes a functional member of the novel subfamily of the ubp family defined by the human homologue UBH1, thus implicating ubiquitination in the process of carbon catabolite repression. Members of the novel subfamily of ubps that include CreB are widespread amongst eukaryotes, with homologues present in mammals, nematodes, Drosophila and Arabidopsis, but mutations in the genes have only been identified in A. nidulans. From phenotypes of the A. nidulans mutants it is probable that this subfamily is involved in complex regulatory pathways. Mutations in the gene encoding the WD40 repeat protein CreC result in an identical phenotype, implicating both genes in this pathway.
dc.description.statementofresponsibilityRobin A. Lockington and Joan M. Kelly
dc.identifier.citationMolecular Microbiology, 2001; 40(6):1311-1321
dc.identifier.doi10.1046/j.1365-2958.2001.02474.x
dc.identifier.issn0950-382X
dc.identifier.issn1365-2958
dc.identifier.urihttp://hdl.handle.net/2440/28097
dc.language.isoen
dc.publisherBlackwell Science Ltd
dc.source.urihttps://doi.org/10.1046/j.1365-2958.2001.02474.x
dc.subjectAspergillus nidulans
dc.subjectCarbon
dc.subjectProtein Kinases
dc.subjectFungal Proteins
dc.subjectRepressor Proteins
dc.subjectUbiquitins
dc.subjectCloning, Molecular
dc.subjectSuppression, Genetic
dc.subjectAmino Acid Sequence
dc.subjectBase Sequence
dc.subjectConserved Sequence
dc.subjectMutation
dc.subjectMolecular Sequence Data
dc.subjectCyclic AMP Response Element-Binding Protein
dc.titleCarbon catabolite repression in Aspergillus nidulans involves deubiquitination
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Molecular and Biomedical Science publications