Hollow carbon nanospheres with tunable hierarchical pores for drug, gene, and photothermal synergistic treatment

Simple item page
dc.contributor.authorDu, X.
dc.contributor.authorZhao, C.
dc.contributor.authorZhou, M.
dc.contributor.authorMa, T.
dc.contributor.authorHuang, H.
dc.contributor.authorJaroniec, M.
dc.contributor.authorZhang, X.
dc.contributor.authorQiao, S.
dc.date.issued2017
dc.description.abstractDesign and synthesis of porous and hollow carbon spheres have attracted considerable interest in the past decade due to their superior physicochemical properties and widespread applications. However, it is still a big challenge to achieve controllable synthesis of hollow carbon nanospheres with center-radial large mesopores in the shells and inner surface roughness. Herein, porous hollow carbon nanospheres (PHCNs) are successfully synthesized with tunable center-radial mesopore channels in the shells and crater-like inner surfaces by employing dendrimer-like mesoporous silica nanospheres (DMSNs) as hard templates. Compared with conventional mesoporous nanospheres, DMSN templates not only result in the formation of center-radial large mesopores in the shells, but also produce a crater-like inner surface. PHCNs can be tuned from open center-radial mesoporous shells to relatively closed microporous shells. After functionalization with polyethyleneimine (PEI) and poly(ethylene glycol) (PEG), PHCNs not only have negligible cytotoxicity, excellent photothermal property, and high coloading capacity of 482 µg of doxorubicin and 44 µg of siRNA per mg, but can also efficiently deliver these substances into cells, thus displaying enhanced cancer cell killing capacity by triple-combination therapy.
dc.description.statementofresponsibilityXin Du, Caixia Zhao, Mengyun Zhou, Tianyi Ma, Hongwei Huang, Mietek Jaroniec, Xueji Zhang and Shi-Zhang Qiao
dc.identifier.citationSmall, 2017; 13(6):1602592-1-1602592-11
dc.identifier.doi10.1002/smll.201602592
dc.identifier.issn1613-6810
dc.identifier.issn1613-6829
dc.identifier.orcidQiao, S. [0000-0002-1220-1761] [0000-0002-4568-8422]
dc.identifier.urihttp://hdl.handle.net/2440/105652
dc.language.isoen
dc.publisherWiley
dc.relation.granthttp://purl.org/au-research/grants/arc/DP130104459
dc.relation.granthttp://purl.org/au-research/grants/arc/DP140104062
dc.relation.granthttp://purl.org/au-research/grants/arc/DP160104866
dc.rights© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
dc.source.urihttps://doi.org/10.1002/smll.201602592
dc.subjectdelivery nanosystems
dc.subjectdendrimer-like silica nanospheres
dc.subjecthollow carbon nanospheres
dc.subjecttriple-combination therapy
dc.subjecttunable hierarchical structures
dc.titleHollow carbon nanospheres with tunable hierarchical pores for drug, gene, and photothermal synergistic treatment
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Chemical Engineering publications