Derivatization of 1-phenyl substituted 4-amino-2-benzazepin-3-ones: evaluation of Pd-catalyzed coupling reactions
Date
2007
Authors
Ballet, Steven
De Wachter, Rien
Maes, Bert U. W.
Tourwe, Dirk
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Tetrahedron, 2007; 63(18):3718-3727
Statement of Responsibility
Steven Ballet, Rien De Wachter, Bert U.W. Maes, Dirk Tourwé
Conference Name
Abstract
Several Pd-catalyzed reactions were explored to further functionalize the bromo-substituted 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one scaffold (Aba). We report in this paper suitable reaction conditions for Suzuki, Buchwald–Hartwig, and Heck reactions. The substitution pattern of the starting aminobenzazepinone turned out to be crucial for the success of these transition metal-catalyzed reactions, which often required modifications of standard literature procedures. The Pd-catalyzed methods provide access to novel substitution patterns of the Aba scaffold.
School/Discipline
School of Chemistry and Physics : Chemistry