Insulin-like growth factor-I and the gastrointestinal system: Therapeutic indications and safety implications
| dc.contributor.author | Howarth, G. | |
| dc.date.issued | 2003 | |
| dc.description.abstract | Following the identification of insulin-like growth factor-I (IGF-I) as a potent trophic factor for the intestine over a decade ago, therapeutic indications have been identified for a range of candidate bowel disorders and diseases in which accelerated intestinal repair is desirable. Subsequent experimental studies in experimentally-induced animal models and genetically-modified mice have supported a therapeutic role for IGF-I in facilitated repair processes in gastrointestinal disorders including radiation enteritis, chemotherapy-induced mucositis and inflammatory bowel disease, conditions associated with either the pre-existence of malignancy or a predisposition to develop neoplasia. Moreover, recent evidence from in vitro, in vivo and human population studies is suggestive of an active role for IGF-I in the development and progression of certain cancers, and although causality remains unproven, antagonism of IGF-I action is being pursued as a potential chemo-preventive strategy. Novel milk and colostrum-derived bioactive formulations containing IGF-I are being developed as adjunctive treatment modalities for certain bowel disorders. Understanding the precise role of the IGF axis in cancer will either identify antagonism of the IGF-I/receptor interaction as an important approach in cancer prevention and risk reduction, or alternatively, support further development of IGF-I as a promising treatment modality for acute gastrointestinal disease. | |
| dc.identifier.citation | Journal of Nutrition, 2003; 133(7):2109-2112 | |
| dc.identifier.doi | 10.1093/jn/133.7.2109 | |
| dc.identifier.issn | 0022-3166 | |
| dc.identifier.issn | 1541-6100 | |
| dc.identifier.orcid | Howarth, G. [0000-0001-6979-6084] | |
| dc.identifier.uri | http://hdl.handle.net/2440/7544 | |
| dc.language.iso | en | |
| dc.publisher | Amer Inst Nutrition | |
| dc.source.uri | http://jn.nutrition.org/cgi/content/abstract/133/7/2109 | |
| dc.subject | Insulin-like growth factor-I | |
| dc.subject | intestine | |
| dc.subject | disease | |
| dc.subject | treatment | |
| dc.subject | cancer | |
| dc.subject | risk | |
| dc.title | Insulin-like growth factor-I and the gastrointestinal system: Therapeutic indications and safety implications | |
| dc.type | Journal article | |
| pubs.publication-status | Published |