Anti-mullerian hormone as a marker of ovarian reserve

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dc.contributor.authorTremellen, K.
dc.contributor.authorKolo, M.
dc.contributor.authorGilmore, T.
dc.contributor.authorLekamge, D.
dc.date.issued2005
dc.description.abstract<h4>Objective</h4>To analyse the usefulness of plasma anti-mullerian hormone (AMH) measurement as a tool for assessing ovarian reserve in a general infertility population.<h4>Materials and methods</h4>Plasma AMH levels were analysed in 238 women aged 18-46 years during day 3-5 of their menstrual cycle. All 238 patients had follicle stimulating hormone (FSH) levels less than 10 i.u./L, suggesting normal ovarian reserve on traditional FSH criteria. Eighty-seven patients gave their consent to correlate their AMH levels with IVF oocyte retrieval outcome. Patients producing > or = 8 oocytes were classified as having normal ovarian reserve, while those producing < or = 4 oocytes were classified as having poor ovarian reserve.<h4>Results</h4>Plasma AMH levels remained relatively static (20-25 pmol/L) from 18 to 29 years of age. By 30 years of age, plasma AMH levels start to drop rapidly, reaching only 10 pmol/L by 37 years. Despite this 50% fall in AMH levels between 29 and 37 years of age, minimal changes in FSH levels were observed. Using a cut off value of 8.1 pmol/L, plasma AMH assessment could predict poor ovarian reserve on a subsequent IVF cycle with a sensitivity of 80% and a specificity of 85%.<h4>Conclusions</h4>Plasma AMH assessments are superior to FSH in identifying women with reduced ovarian reserve. Anti-mullerian hormone assessment should be considered as a useful adjunct to FSH/oestradiol levels and antral follicle count when estimating ovarian reserve.
dc.identifier.citationAustralian and New Zealand Journal of Obstetrics and Gynaecology, 2005; 45(1):20-24
dc.identifier.doi10.1111/j.1479-828X.2005.00332.x
dc.identifier.issn0004-8666
dc.identifier.issn1479-828X
dc.identifier.urihttp://hdl.handle.net/2440/17260
dc.language.isoen
dc.publisherBlackwell Publishing Asia
dc.source.urihttps://doi.org/10.1111/j.1479-828x.2005.00332.x
dc.subjectOvary
dc.subjectOocytes
dc.subjectHumans
dc.subjectTesticular Hormones
dc.subjectGlycoproteins
dc.subjectFertilization in Vitro
dc.subjectCell Count
dc.subjectFollicular Phase
dc.subjectAdolescent
dc.subjectAdult
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectAnti-Mullerian Hormone
dc.subjectBiomarkers
dc.titleAnti-mullerian hormone as a marker of ovarian reserve
dc.typeJournal article
pubs.publication-statusPublished

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