Distribution of a putative endothelial barrier antigen in the ocular and orbital tissues of the rat

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dc.contributor.authorLawrenson, J.
dc.contributor.authorGhabriel, M.
dc.contributor.authorReid, A.
dc.contributor.authorGajree, T.
dc.contributor.authorAllt, G.
dc.date.issued1995
dc.description.abstractBACKGROUND--A rat endothelial barrier antigen (EBA) recognised by a monoclonal antibody has been shown to be expressed strongly by endothelial cells of brain capillaries possessing a blood-brain barrier and only weakly expressed by fenestrated brain vessels. METHODS--In this study immunocytochemical methods for light and electron microscopy were used to study EBA distribution in the eye and orbital tissues of the rat. RESULTS--Blood-ocular barrier vessels in the optic nerve, retina, iris, and some vessels in th choroid and ciliary body were immunopositive for EBA. By pre-embedding immunocytochemistry for electron microscopy the antigen was observed on the luminal endothelial cell surface. CONCLUSION--Surprisingly, some non-barrier vessels in the ciliary body and choroid expressed EBA suggesting that it may play a broader role in endothelial properties than previously recognised. The functional significance of EBA remains to be elucidated.
dc.description.statementofresponsibilityJ G Lawrenson, Mounir N Ghabriel, A R Reid, T N Gajree, and G Allt
dc.identifier.citationBritish Journal of Ophthalmology, 1995; 79(5):462-466
dc.identifier.doi10.1136/bjo.79.5.462
dc.identifier.issn0007-1161
dc.identifier.issn1468-2079
dc.identifier.orcidGhabriel, M. [0000-0002-9153-271X]
dc.identifier.urihttp://hdl.handle.net/2440/5339
dc.language.isoen
dc.publisherBMJ Publishing Group
dc.source.urihttps://doi.org/10.1136/bjo.79.5.462
dc.subjectEye
dc.subjectOrbit
dc.subjectBlood-Brain Barrier
dc.subjectOptic Nerve
dc.subjectRetina
dc.subjectChoroid
dc.subjectCiliary Body
dc.subjectIris
dc.subjectAnimals
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectAntigens, Surface
dc.subjectMicroscopy, Immunoelectron
dc.subjectImmunohistochemistry
dc.subjectMale
dc.titleDistribution of a putative endothelial barrier antigen in the ocular and orbital tissues of the rat
dc.typeJournal article
pubs.publication-statusPublished

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