Quantitative computed tomography predicts outcomes in idiopathic pulmonary fibrosis

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dc.contributor.authorHumphries, S.M.
dc.contributor.authorMackintosh, J.A.
dc.contributor.authorJo, H.E.
dc.contributor.authorWalsh, S.L.F.
dc.contributor.authorSilva, M.
dc.contributor.authorCalandriello, L.
dc.contributor.authorChapman, S.
dc.contributor.authorEllis, S.
dc.contributor.authorGlaspole, I.
dc.contributor.authorGoh, N.
dc.contributor.authorGrainge, C.
dc.contributor.authorHopkins, P.M.A.
dc.contributor.authorKeir, G.J.
dc.contributor.authorMoodley, Y.
dc.contributor.authorReynolds, P.N.
dc.contributor.authorWalters, E.H.
dc.contributor.authorBaraghoshi, D.
dc.contributor.authorWells, A.U.
dc.contributor.authorLynch, D.A.
dc.contributor.authorCorte, T.J.
dc.date.issued2022
dc.descriptionFirst published: 25 July 2022
dc.description.abstractBackground and objective: Prediction of disease course in patients with progressive pulmonary fibrosis remains challenging. The purpose of this study was to assess the prognostic value of lung fibrosis extent quantified at computed tomography (CT) using data-driven texture analysis (DTA) in a large cohort of well-characterized patients with idiopathic pulmonary fibrosis (IPF) enrolled in a national registry. Methods: This retrospective analysis included participants in the Australian IPF Registry with available CT between 2007 and 2016. CT scans were analysed using the DTA method to quantify the extent of lung fibrosis. Demographics, longitudinal pulmonary function and quantitative CT metrics were compared using descriptive statistics. Linear mixed models, and Cox analyses adjusted for age, gender, BMI, smoking history and treatment with anti-fibrotics were performed to assess the relationships between baseline DTA, pulmonary function metrics and outcomes. Results: CT scans of 393 participants were analysed, 221 of which had available pulmonary function testing obtained within 90 days of CT. Linear mixed-effect modelling showed that baseline DTA score was significantly associated with annual rate of decline in forced vital capacity and diffusing capacity of carbon monoxide. In multivariable Cox proportional hazard models, greater extent of lung fibrosis was associated with poorer transplant-free survival (hazard ratio [HR] 1.20, p < 0.0001) and progression-free survival (HR 1.14, p < 0.0001). Conclusion: In a multi-centre observational registry of patients with IPF, the extent of fibrotic abnormality on baseline CT quantified using DTA is associated with outcomes independent of pulmonary function.
dc.description.statementofresponsibilityStephen M. Humphries, John A. Mackintosh, Helen E. Jo, Simon L. F. Walsh, Mario Silva, Lucio Calandriello, Sally Chapman, Samantha Ellis, Ian Glaspole, Nicole Goh, Christopher Grainge, Peter M. A. Hopkins, Gregory J. Keir, Yuben Moodley, Paul N. Reynolds, E. Haydn Walters, David Baraghoshi, Athol U. Wells, David A. Lynch, Tamera J. Corte
dc.identifier.citationRespirology, 2022; 27(12):1045-1053
dc.identifier.doi10.1111/resp.14333
dc.identifier.issn1323-7799
dc.identifier.issn1440-1843
dc.identifier.orcidReynolds, P.N. [0000-0002-2273-1774]
dc.identifier.urihttps://hdl.handle.net/2440/135976
dc.language.isoen
dc.publisherWiley
dc.relation.grantNHMRC
dc.rights© 2022 The Authors. Respirology published by John Wiley & Sons Australia, Ltd on behalf of Asian Pacific Society of Respirology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
dc.source.urihttps://doi.org/10.1111/resp.14333
dc.subjectdata-driven texture analysis; idiopathic pulmonary fibrosis; pulmonary function; quantitative computed tomography
dc.titleQuantitative computed tomography predicts outcomes in idiopathic pulmonary fibrosis
dc.typeJournal article
pubs.publication-statusPublished

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