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Antibody-functionalized porous silicon nanoparticles for vectorization of hydrophobic drugs

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dc.contributor.authorSecret, E.
dc.contributor.authorSmith, K.
dc.contributor.authorDubljevic, V.
dc.contributor.authorMoore, E.
dc.contributor.authorMacardle, P.
dc.contributor.authorDelalat, B.
dc.contributor.authorRogers, M.L.
dc.contributor.authorJohns, T.G.
dc.contributor.authorDurand, J.O.
dc.contributor.authorCunin, F.
dc.contributor.authorVoelcker, N.H.
dc.date.issued2013
dc.description.abstractWe describe the preparation of biodegradable porous silicon nanoparticles (pSiNP) functionalized with cancer cell targeting antibodies and loaded with the hydrophobic anti-cancer drug camptothecin. Orientated immobilization of the antibody on the pSiNP is achieved using novel semicarbazide based bioconjugate chemistry. To demonstrate the generality of this targeting approach, the three antibodies MLR2, mAb528 and Rituximab are used, which target neuroblastoma, glioblastoma and B lymphoma cells, respectively. Successful targeting is demonstrated by means of flow cytometry and immunocytochemistry both with cell lines and primary cells. Cell viability assays after incubation with pSiNPs show selective killing of cells expressing the receptor corresponding to the antibody attached on the pSiNP.
dc.identifier.citationAdvanced healthcare materials, 2013; 2(5):718-727
dc.identifier.doi10.1002/adhm.201200335
dc.identifier.issn2192-2640
dc.identifier.issn2192-2659
dc.identifier.urihttps://hdl.handle.net/1959.8/125312
dc.language.isoen
dc.publisherWiley-VCH Verlag GmbH
dc.relation.fundingPHC FAST 2011 Program 24136Y
dc.rightsCopyright 2013 Wiley-VCH GmbH Access Condition Notes: Preprint only available on Open Access
dc.source.urihttps://doi.org/10.1002/adhm.201200335
dc.subjectantibodies
dc.subjectantineoplastic agents
dc.subjectcamptothecin
dc.subjectcell line
dc.subjectdiffusion
dc.subjecthydrophobic and hydrophilic interactions
dc.subjectmaterials testing
dc.subjectnanocapsules
dc.subjectneoplasms
dc.subjectporosity
dc.subjectsilicon/chemistry
dc.titleAntibody-functionalized porous silicon nanoparticles for vectorization of hydrophobic drugs
dc.typeJournal article
pubs.publication-statusPublished
ror.fileinfo12143169470001831 13143168740001831 9915914118401831_53109919510001831.pdf
ror.mmsid9915914118401831

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