Phenytoin infusion revisited: stability and administration
| dc.contributor.author | Milne, D. | |
| dc.contributor.author | Foo, J.H.M. | |
| dc.contributor.author | Sharley, N. | |
| dc.contributor.author | Milne, R.W. | |
| dc.date.issued | 2004 | |
| dc.description.abstract | <jats:p><jats:bold>Background</jats:bold>Manufacturers of phenytoin injection recommend that it be given without dilution by direct IV injection. Direct IV injection presents well‐recognised side effects which can be minimised by giving phenytoin as an infusion.</jats:p><jats:p><jats:bold>Aim:</jats:bold>To assess the stability of Phenytoin Injection (DBL) in sodium chloride 0.9% prepared for infusion in Viaflex bags and a Buretrol extension set.</jats:p><jats:p><jats:bold>Method:</jats:bold>Admixtures containing 3, 6 and 10 mg/mL of phenytoin were prepared in sodium chloride 0.9% and stored in Viaflex bags, extension sets and beakers exposed to air (controls) for 6 hours. The concentration of phenytoin in the Viaflex bags was measured by UV absorption spectrophotometry. All the admixtures were inspected for microscopic particulate matter and the pH measured at intervals over 6 hours.</jats:p><jats:p><jats:bold>Results:</jats:bold>In the Viaflex bags there were no changes in the phenytoin concentration, minimal change in pH(< 0.1) and no particulate matter over 6 hours. In the extension sets and beakers, particulate matter was minimal at 2 hours and extensive beyond this time. There was an overall decrease of 0.30 and 0.32 pH units in samples from the extension sets and beakers.</jats:p><jats:p><jats:bold>Conclusion:</jats:bold>Phenytoin Injection (DBL) can be given as an IV infusion in sodium chloride 0.9% provided it is prepared in a Viaflex bag and infused within 2 hours of preparation.</jats:p><jats:p><jats:bold>J Pharm Pract Res 2004; 34: 272–5.</jats:bold></jats:p> | |
| dc.identifier.citation | Journal of Pharmacy Practice and Research, 2004; 34(4):272-275 | |
| dc.identifier.doi | 10.1002/jppr2004344272 | |
| dc.identifier.issn | 1445-937X | |
| dc.identifier.issn | 2055-2335 | |
| dc.identifier.uri | https://hdl.handle.net/1959.8/26248 | |
| dc.language.iso | en | |
| dc.publisher | Society of Hospital Pharmacists of Australia | |
| dc.rights | Copyright status unknown | |
| dc.source.uri | https://doi.org/10.1002/jppr2004344272 | |
| dc.subject | phenytoin | |
| dc.subject | stability | |
| dc.subject | administration | |
| dc.title | Phenytoin infusion revisited: stability and administration | |
| dc.type | Journal article | |
| pubs.publication-status | Published | |
| ror.mmsid | 9915913381501831 |