Beyond the gastrointestinal cell layer : replication of the complex oral absorption barrier through enhanced in vitro models for nanoparticulate oral protein delivery /
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(Published version)
Date
2022
Authors
Wright, Leah
Editors
Advisors
Journal Title
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Volume Title
Type:
thesis
Citation
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Abstract
Biological molecules are increasing in prevalence as therapeutic treatments. In addition, their encapsulation within nanoparticles is a popular strategy to help overcome complex hurdles within the body for efficient absorption. Despite this, it is often unclear how the choice of nanoparticle material influences its interaction with the body. This thesis explores how this choice of material influences the ability for nanoparticles to absorb into intestinal cells and cross the intestinal mucus layer. In particular, reliable analysis models of the intestinal mucus are lacking. This thesis explores how the currently available models can be improved to more closely replicate the natural intestinal mucus. Knowledge gained allows researchers to more efficiently choose particle materials for formulation development, and improves our current lab models to increase their predictive capacity.
School/Discipline
University of South Australia. UniSA Clinical and Health Sciences.
UniSA Clinical and Health Sciences
UniSA Clinical and Health Sciences
Dissertation Note
Thesis (PhD(Pharmaceutical Science))--University of South Australia, 2022.
Provenance
Copyright 2022 Leah Wright.
Description
1 ethesis (xxii, 109 pages) :
illustrations (chiefly colour), charts (chiefly colour)
Includes bibliographical references.
illustrations (chiefly colour), charts (chiefly colour)
Includes bibliographical references.
Access Status
506 0#$fstar $2Unrestricted online access