Current studentsExisting staffContact us
 

Diversity of cancer stem cells in head and neck carcinomas: The role of HPV in cancer stem cell heterogeneity, plasticity and treatment response

Simple item page
dc.contributor.authorReid, P.
dc.contributor.authorMarcu, L.G.
dc.contributor.authorOlver, I.
dc.contributor.authorMoghaddasi, L.
dc.contributor.authorStaudacher, A.H.
dc.contributor.authorBezak, E.
dc.date.issued2019
dc.description.abstractHead and neck squamous cell carcinomas (HNSCC) resulting from oncogenic transformations following human papillomavirus (HPV) infection consistently demonstrate better treatment outcomes than HNSCC from other aetiologies. Squamous cell carcinoma of the oropharynx (OPSCC) shows the highest prevalence of HPV involvement at around 70-80%. While strongly prognostic, HPV status alone is not sufficient to predict therapy response or any potential dose de-escalation. Cancer stem cell (CSC) populations within these tumour types represent the most therapy-resistant cells and are the source of recurrence and metastases, setting a benchmark for tumour control. This review examines clinical and preclinical evidence of differences in response to treatment by the HPV statuses of HNSCC and the role played by CSCs in treatment resistance and their repopulation from non-CSCs. Evidence was collated from literature searches of PubMed, Scopus and Ovid for differential treatment response by HPV status and contribution by critical biomarkers including CSC fractions and chemo-radiosensitivity. While HPV and CSC are yet to fulfil promise as biomarkers of treatment response, understanding how HPV positive and negative aetiologies affect CSC response to treatment and tumour plasticity will facilitate their use for greater treatment individualisation.
dc.identifier.citationRadiotherapy and Oncology, 2019; 135:1-12
dc.identifier.doi10.1016/j.radonc.2019.02.016
dc.identifier.issn0167-8140
dc.identifier.issn1879-0887
dc.identifier.orcidOlver, I. [0000-0001-5478-1576]
dc.identifier.orcidStaudacher, A.H. [0000-0001-5034-9532]
dc.identifier.orcidBezak, E. [0000-0002-1315-1735] [0000-0003-0084-4089]
dc.identifier.urihttps://hdl.handle.net/11541.2/136354
dc.language.isoen
dc.publisherELSEVIER IRELAND LTD
dc.rightsCopyright 2019 Elsevier
dc.source.urihttps://doi.org/10.1016/j.radonc.2019.02.016
dc.subjectCancer Stem Cell
dc.subjectHNSCC
dc.subjectHPV
dc.subjectHead and neck cancer
dc.subjectOPSCC
dc.subjectRadio-chemotherapy
dc.titleDiversity of cancer stem cells in head and neck carcinomas: The role of HPV in cancer stem cell heterogeneity, plasticity and treatment response
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9916267909801831

Files

Collections