Gene therapy approaches to prolonging corneal allograft survival

Simple item page
dc.contributor.authorWilliams, K.
dc.contributor.authorJessup, C.
dc.contributor.authorCoster, D.
dc.date.issued2004
dc.description.abstractIrreversible immunological rejection is the major cause of human corneal allograft failure and occurs despite the use of topical glucocorticoid immunosuppression. Systemic pharmacological interventions have not found widespread favour in corneal transplantation because of associated morbidities and inadequate demonstration of efficacy. Gene therapy offers tantalising prospects for improving corneal allograft survival, especially in those recipients at high risk of graft rejection. Donor corneas can be gene-modified ex vivo, while in storage prior to implantation, and the relative isolation of the transplanted cornea from the circulation decreases the risk of potential systemic complications. A wide variety of vectors have been found suitable for gene transfer to the cornea. The mechanisms involved in corneal graft rejection have been placed on a relatively secure footing over the past decade and in consequence a number of transgenes with promise for modulating rejection have been identified. However, relatively few studies have thus far demonstrated significant prolongation of corneal allograft survival after gene transfer to the donor cornea. In these instances, the therapeutic protein almost certainly acted at a proximal level in the afferent immune response, within the ocular environs.
dc.description.statementofresponsibilityKeryn A. Williams, Claire F. Jessup and Douglas J. Coster
dc.identifier.citationExpert Opinion on Biological Therapy, 2004; 4(7):1059-1071
dc.identifier.doi10.1517/14712598.4.7.1059
dc.identifier.issn1471-2598
dc.identifier.issn1744-7682
dc.identifier.orcidJessup, C. [0000-0003-1184-6653]
dc.identifier.urihttp://hdl.handle.net/2440/56739
dc.language.isoen
dc.publisherAshley Publications Ltd
dc.source.urihttps://doi.org/10.1517/14712598.4.7.1059
dc.subjectT-Lymphocytes
dc.subjectAnimals
dc.subjectHumans
dc.subjectMice
dc.subjectViruses
dc.subjectCorneal Neovascularization
dc.subjectInflammation
dc.subjectDNA, Recombinant
dc.subjectCytokines
dc.subjectCorneal Transplantation
dc.subjectTransplantation, Homologous
dc.subjectElectroporation
dc.subjectBiolistics
dc.subjectIontophoresis
dc.subjectLife Tables
dc.subjectGraft Rejection
dc.subjectGraft Survival
dc.subjectGenetic Vectors
dc.subjectGenetic Therapy
dc.titleGene therapy approaches to prolonging corneal allograft survival
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Medicine publications