Inhibition of human polymorphonuclear leukocyte respiratory burst, bactericidal activity, and migration by pneumolysin

Simple item page
dc.contributor.authorPaton, J.
dc.contributor.authorFerrante, A.
dc.date.issued1983
dc.description.abstractThe in vitro effects of pneumolysin, a sulfhydryl-activated toxin produced by Streptococcus pneumoniae, on various functions of human polymorphonuclear leukocytes (PMNLs) was investigated. Treatment of PMNLs with highly purified toxin significantly inhibited respiratory burst (in response to stimulation), ability to kill opsonized pneumococci, chemotaxis, and random migration. These inhibitions were observed at very low toxin doses (less than or equal to 1 hemolytic unit (2 ng) per 10(6) PMNLs), which had no effect on PMNL viability. These results suggest that pneumolysin could function in pathogenicity by interfering with the ability of PMNLs to migrate toward and kill pneumococci.
dc.description.statementofresponsibilityJames C. Paton and Antonio Ferrante
dc.identifier.citationInfection and Immunity, 1983; 41(3):1212-1216
dc.identifier.doi10.1128/iai.41.3.1212-1216.1983
dc.identifier.issn0019-9567
dc.identifier.issn1098-5522
dc.identifier.orcidPaton, J. [0000-0001-9807-5278]
dc.identifier.orcidFerrante, A. [0000-0002-2581-6407]
dc.identifier.urihttp://hdl.handle.net/2440/85784
dc.language.isoen
dc.publisherAmerican Society for Microbiology
dc.rights© 1983, American Society for Microbiology
dc.source.urihttp://iai.asm.org/content/41/3/1212
dc.subjectNeutrophils
dc.subjectHumans
dc.subjectHydrogen Peroxide
dc.subjectBacterial Proteins
dc.subjectStreptolysins
dc.subjectCell Migration Inhibition
dc.subjectChemotaxis, Leukocyte
dc.subjectPhagocytosis
dc.subjectOxygen Consumption
dc.subjectDose-Response Relationship, Drug
dc.titleInhibition of human polymorphonuclear leukocyte respiratory burst, bactericidal activity, and migration by pneumolysin
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Molecular and Biomedical Science publications