Current studentsExisting staffContact us
 

Association of genetic loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children

Simple item page
dc.contributor.authorBarker, A.
dc.contributor.authorSharp, S.
dc.contributor.authorTimpson, N.
dc.contributor.authorBouatia-Naji, N.
dc.contributor.authorWarrington, N.
dc.contributor.authorKanoni, S.
dc.contributor.authorBeilin, L.
dc.contributor.authorBrage, S.
dc.contributor.authorDeloukas, P.
dc.contributor.authorEvans, D.
dc.contributor.authorGrontved, A.
dc.contributor.authorHassanali, N.
dc.contributor.authorLawlor, D.
dc.contributor.authorLecoeur, C.
dc.contributor.authorLoos, R.
dc.contributor.authorLye, S.
dc.contributor.authorMcCarthy, M.
dc.contributor.authorMori, T.
dc.contributor.authorCoumba Ndiaye, N.
dc.contributor.authorNewnham, J.
dc.contributor.authoret al.
dc.date.issued2011
dc.description.abstractOBJECTIVE To investigate whether associations of common genetic variants recently identified for fasting glucose or insulin levels in nondiabetic adults are detectable in healthy children and adolescents. RESEARCH DESIGN AND METHODS A total of 16 single nucleotide polymorphisms (SNPs) associated with fasting glucose were genotyped in six studies of children and adolescents of European origin, including over 6,000 boys and girls aged 9–16 years. We performed meta-analyses to test associations of individual SNPs and a weighted risk score of the 16 loci with fasting glucose. RESULTS Nine loci were associated with glucose levels in healthy children and adolescents, with four of these associations reported in previous studies and five reported here for the first time (GLIS3, PROX1, SLC2A2, ADCY5, and CRY2). Effect sizes were similar to those in adults, suggesting age-independent effects of these fasting glucose loci. Children and adolescents carrying glucose-raising alleles of G6PC2, MTNR1B, GCK, and GLIS3 also showed reduced β-cell function, as indicated by homeostasis model assessment of β-cell function. Analysis using a weighted risk score showed an increase [β (95% CI)] in fasting glucose level of 0.026 mmol/L (0.021–0.031) for each unit increase in the score. CONCLUSIONS Novel fasting glucose loci identified in genome-wide association studies of adults are associated with altered fasting glucose levels in healthy children and adolescents with effect sizes comparable to adults. In nondiabetic adults, fasting glucose changes little over time, and our results suggest that age-independent effects of fasting glucose loci contribute to long-term interindividual differences in glucose levels from childhood onwards.
dc.description.statementofresponsibilityAdam Barker ... Lyle J. Palmer .. et al.
dc.identifier.citationDiabetes, 2011; 60(6):1805-1812
dc.identifier.doi10.2337/db10-1575
dc.identifier.issn0012-1797
dc.identifier.issn1939-327X
dc.identifier.orcidLawlor, D. [0000-0002-6793-2262]
dc.identifier.urihttp://hdl.handle.net/2440/88538
dc.language.isoen
dc.publisherAmerican Diabetes Association
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/572613
dc.rights© 2011 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by -nc-nd/3.0/ for details.
dc.source.urihttps://doi.org/10.2337/db10-1575
dc.subjectHumans
dc.subjectGlucose-6-Phosphatase
dc.subjectBlood Glucose
dc.subjectDNA-Binding Proteins
dc.subjectHomeodomain Proteins
dc.subjectTrans-Activators
dc.subjectTumor Suppressor Proteins
dc.subjectTranscription Factors
dc.subjectRepressor Proteins
dc.subjectFasting
dc.subjectPolymorphism, Single Nucleotide
dc.subjectAdolescent
dc.subjectChild
dc.subjectFemale
dc.subjectMale
dc.subjectGlucose Transporter Type 2
dc.subjectGenome-Wide Association Study
dc.subjectGenetic Loci
dc.subjectCryptochromes
dc.subjectAdenylyl Cyclases
dc.subjectGerminal Center Kinases
dc.subjectProtein Serine-Threonine Kinases
dc.subjectProspero-Related Homeobox 1 Protein
dc.titleAssociation of genetic loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children
dc.typeJournal article
pubs.publication-statusPublished

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
hdl_88538.pdf
Size:
932.02 KB
Format:
Adobe Portable Document Format
Description:
Published version
Download

Collections

Translational Health Science publications