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TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target

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dc.contributor.authorUllah, M.
dc.contributor.authorSweet, M.
dc.contributor.authorMansell, A.
dc.contributor.authorKellie, S.
dc.contributor.authorKobe, B.
dc.date.issued2016
dc.description.abstractToll/IL-1R domain-containing adaptor-inducing IFN-β (TRIF)-dependent signaling is required for TLR-mediated production of type-I IFN and several other proinflammatory mediators. Various pathogens target the signaling molecules and transcriptional regulators acting in the TRIF pathway, thus demonstrating the importance of this pathway in host defense. Indeed, the TRIF pathway contributes to control of both viral and bacterial pathogens through promotion of inflammatory mediators and activation of antimicrobial responses. TRIF signaling also has both protective and pathologic roles in several chronic inflammatory disease conditions, as well as an essential function in wound-repair processes. Here, we review our current understanding of the regulatory mechanisms that control TRIF-dependent TLR signaling, the role of the TRIF pathway in different infectious and noninfectious pathologic states, and the potential for manipulating TRIF-dependent TLR signaling for therapeutic benefit.
dc.description.statementofresponsibilityM. Obayed Ullah, Matthew J. Sweet, Ashley Mansell, Stuart Kellie, and Bostjan Kobe
dc.identifier.citationJournal of Leukocyte Biology, 2016; 100(1):27-45
dc.identifier.doi10.1189/jlb.2RI1115-531R
dc.identifier.issn0741-5400
dc.identifier.issn1938-3673
dc.identifier.orcidUllah, M. [0000-0002-1175-3636]
dc.identifier.urihttp://hdl.handle.net/2440/104985
dc.language.isoen
dc.publisherFederation of American Societies for Experimental Biology
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1003326
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1107804
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1071659
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1003325
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1110971
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1107914
dc.rights© 2016 Society for Leukocyte Biology
dc.source.urihttps://doi.org/10.1189/jlb.2ri1115-531r
dc.subjectAdaptor protein
dc.subjectinnate immunity
dc.subjectpattern recognition receptor
dc.titleTRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target
dc.typeJournal article
pubs.publication-statusPublished

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